ArticleDiagnostic pathology2020
Perianal Paget's disease: a clinicopathological and immunohistochemical study of 13 cases.
Article in Diagnostic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Perianal Intestinal-Type Paget Disease With and Without Invasion, Unassociated With Internal Malignancy: A Distinct Form of Primary Perianal Adenocarcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2026Article
- Diagnostic Algorithm for Secondary Extramammary Paget Disease from Institutional Cases and Literature Review.Cancers · 2025Article
- Article
- Article
- Perianal Paget's Disease: A Challenge of Surgical Margins in Uncommon Clinical Presentations.Cureus · 2025Article
- Case Report: A case study of perianal paget's disease in a patient receiving adjuvant photodynamic therapy post-surgery.Frontiers in surgery · 2025Article
- Utility of special AT-rich sequence-binding protein 2 (SATB2) immunohistochemistry as a marker for secondary perianal paget disease.Virchows Archiv : an international journal of pathology · 2024Article
- Re: Erythematous Plaque in the Left Axillary Region: A diagnostic challenge where dermoscopy can help.Sultan Qaboos University medical journal · 2024Article
- The elusive extremities: a case of extramammary Paget disease.BMJ case reports · 2024Article
- Rectal Adenocarcinoma With Pagetoid Spread: A Novel Entity.Case reports in gastrointestinal medicine · 2024Article
- Article
- Erythematous Plaque in the Left Axillary Region: A diagnostic challenge where dermoscopy can help.Sultan Qaboos University medical journal · 2023Article
- Perianal PagetZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Review
- The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Review
- The Clinical Characteristics and Prognostic Factors of Primary Extramammary Paget's Disease Treated with Surgery in Anogenital Regions: A Large Population Study from the SEER Database and Our Centre.Journal of clinical medicine · 2023Article
- Perianal Paget disease associated with non-invasive colorectal adenoma.Journal of cutaneous pathology · 2023Article
- Hepatic metastasis from perianal Paget's disease without identified underlying carcinoma: a case report.World journal of surgical oncology · 2021Article
- Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.Current oncology (Toronto, Ont.) · 2021Review
- Perianal Paget's disease: one century later and still a challenge.BMJ case reports · 2021Article
- Perianal Paget's disease as spread from non-invasive colorectal adenomas.Histopathology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPerianal Paget's disease (PPD) is rare and mostly described in clinical literature as case reports or small series.
methodsWe investigated the clinicopathologic and immunohistochemical features of PPD in a total of 13 cases retrieved from multiple academic institutions.
resultsThe median age at diagnosis was 75 (range 50-86) years. Males were predominant with a male to female ratio of 2.25:1. Four (30.8%) cases were classified as primary PPD due to lack of synchronous or metachronous underlying malignancies, while nine (69.2%) were classified as secondary PPD with concurrent invasive adenocarcinoma (n = 8) or tubular adenoma with high-grade dysplasia (n = 1). Immunohistochemically, there is no differential expression of CK7 or CK20 in Paget's cells between primary and secondary PPD; however, GCDFP-15 was only positive in primary PPD (3/3 vs. 0/6, P = 0.012), while CDX2 was only positive in secondary PPD (0/3 vs. 7/7, P = 0.008), suggesting different cell origin. All patients received local surgical resection with or without adjuvant therapy. After a median follow-up of 47 months, one patient with secondary PPD (7.7%) died of disease progression from underlying adenocarcinoma.
conclusionsPPD occurs in elderly patients with male predominance and is frequently associated with underlying malignancies. Differential expression of CDX2 and GCDFP-15 may help distinguishing primary vs. secondary PPD, which is important for management as the presence of an underlying malignancy impacts clinical course and prognosis. Surgical excision remains the major treatment strategy for PPD. Long-term follow-up is required to monitor the disease recurrence and metastasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.