Evidence map›Paper›PMID 32209110›Full record

ArticleHarm reduction journal2020

Prevalence and risk factors associated with HIV-1 infection among people who inject drugs in Dar es Salaam, Tanzania: a sign of successful intervention?

Samuel Lazarus Likindikoki, Elia John Mmbaga, Germana Henry Leyna, Kåre Moen, Neema Makyao, Mucho Mizinduko, Alex Ishungisa Mwijage, Diana Faini, Melkizedeck Thomas Leshabari, Dan Wolf Meyrowitsch

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In one paragraph

Article in Harm reduction journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Samuel Lazarus LikindikokiDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, P.O. Box 65001, Dar es Salaam, Tanzania. likindikoki@gmail.com.
Elia John MmbagaDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, P.O. Box 65001, Dar es Salaam, Tanzania.
Germana Henry LeynaDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, P.O. Box 65001, Dar es Salaam, Tanzania.
Kåre MoenDepartment of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway.
Neema MakyaoNational AIDS Control Programme, Ministry of Health, Community Development, Gender, children and Elderly, Dodoma, Tanzania.
Mucho MizindukoDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, P.O. Box 65001, Dar es Salaam, Tanzania.
Alex Ishungisa MwijageDepartment of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Diana FainiDepartment of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, 9 United Nations Road, P.O. Box 65001, Dar es Salaam, Tanzania.
Melkizedeck Thomas LeshabariDepartment of Behavioral Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Dan Wolf MeyrowitschDepartment of Public Health, Global Health Section, University of Copenhagen, Copenhagen, Denmark.
Muhimbili University of Health and Allied Sciences · TZMinistry of Health, Community Development, Gender, Elderly and Children · TZUniversity of Copenhagen · DKUniversity of Oslo · NO

Funding

Tuberculosis Research Institute at MUHASD43TW009573 · FIC · DARTMOUTH COLLEGE · PI ADAMS, LISA VIRGINIA · 2013 to 2022
$3.0M
FIC NIH HHS D43 TW009573
6 · The paper itself

Abstract

backgroundPrevalence of HIV infection among people who inject drugs (PWID) has been reported to be higher than that of the general population. The present study aimed to estimate the prevalence of HIV infection and associated risk factors among PWID in Dar es Salaam, Tanzania, following the introduction of a comprehensive HIV intervention package (CHIP) for PWID in the country in 2014.

methodsWe conducted an integrated bio-behavioral survey (IBBS) among PWID using respondent-driven sampling (RDS) in Dar es Salaam, Tanzania, between October and December 2017. Data on socio-demographic characteristics and risky behaviors were collected through face-to-face interviews. Blood samples were collected and tested for HIV infection. We accounted for weighting in the analyses, and logistic regression was performed to assess risk factors for HIV infection.

resultsA total of 611 PWID (94.4% males and 5.6% females) with a median age of 34 years (IQR 29-38) were recruited. The overall prevalence of HIV infection was 8.7% (95% CI 6.5-10.9). The prevalence of HIV infections for males and females were 6.8% (95% CI 4.7-8.9%) and 41.2% (95% CI 23.7-58.6%) respectively. Adjusted weighted logistic regression analysis (WLRA) showed that being a female (aOR 19.1; 95% CI 5.9-61.8), injecting drugs for more than 10 years (aOR = 7.32; 95% CI 2.1-25.5) compared to 1 year or less and being 45 years or older (aOR = 34.22; 95% CI 2.4-489.5) compared to being 25 years or younger were associated with increased odds of HIV infection. Use of a sterile needle at last injection decreased odds of HIV infection (aOR = 0.3; 95% CI 0.1-0.8).

conclusionsThe present study observed a decline in prevalence of HIV infections among PWID in Dar es Salaam (8.7%) compared to a previous estimate of 15.5% from an IBBS conducted in 2013. Despite the decrease, HIV prevalence remains high among PWID compared to the general population, and women are disproportionally affected. The decline may be possibly attributed to the on-going implementation of CHIP for PWID, highlighting the need for strengthening the existing harm reduction interventions by incorporating access to sterile needle/syringe and addressing the layered risks for women.

Indexed as

AdultComorbidityCross-Sectional StudiesFemaleHIV-1HIV InfectionsHumansMalePrevalenceProgram EvaluationRisk FactorsSubstance Abuse, IntravenousTanzaniaHIVIBBSInjection drug usePrevalenceRisk factorsTanzania

Identifiers

PMID32209110
PMCPMC7092474
OpenAlexW3014083748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.