Evidence map›Paper›PMID 32209093›Full record

ArticleLipids in health and disease2020

Effects of endothelial progenitor cells transplantation on hyperlipidemia associated kidney damage in ApoE knockout mouse model.

Piyun Gong, Zhongwen Zhang, Dongmei Zhang, Zhiwei Zou, Qian Zhang, Huimei Ma, Jingxiu Li, Lin Liao, Jianjun Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. NADCurrent pharmaceutical biotechnology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Piyun GongDepartment of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Zhongwen ZhangDepartment of Endocrinology and Metabology, the First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
Dongmei ZhangDepartment of Cardiovascular Medicine, Ninth Hospital of Xi'an, Xi'an, 710054, China.
Zhiwei ZouDepartment of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Qian ZhangDepartment of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Huimei MaDepartment of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China.
Jingxiu LiQuality control office, People's Hospital of Gaoqing, Zibo, 256300, China.
Lin LiaoDepartment of Endocrinology and Metabology, the First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China. liaolin@sdu.edu.cn.
Jianjun DongDepartment of Endocrinology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, 250012, China. cwc_ll@sdu.edu.cn.
Qilu Hospital of Shandong University · CNNinth Hospital of Nanchang · CNShandong First Medical University · CNShandong University · CN

Funding

National Natural Science Foundation of China No.81570742,81670757,81770822,81800732Natural Science Foundation of Shandong Province No. ZR2016HQ26Natural Science Foundation of Shandong Province NOZR2017LH025Shandong Provincial Medicine and Health Science and Technology Development Program No.2017WS461the Key Research & Development Plan of Shandong Province No. 2018GSF118176
6 · The paper itself

Abstract

backgroundHyperlipidaemia causes kidney damage over the long term. We investigated the effect of the administration of endothelial progenitor cells (EPCs) on the progression of kidney damage in a mouse model of hyperlipidaemia.

methodsApolipoprotein E-knockout (ApoE

resultsApoE

conclusionsOur findings demonstrate that hyperlipidaemia causes basement membrane thickening, glomerulosclerosis and the vascular degeneration of endothelial cells. The long-term administration of EPCs substantially has limited effect in the progression of kidney damage in a mouse model of hyperlipidaemia.

Indexed as

AnimalsApolipoproteins EBlotting, WesternBone Marrow CellsEndothelial Progenitor CellsHyperlipidemiasImmunohistochemistryKidneyMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSmad2 ProteinSmad3 ProteinSplenectomyApolipoproteins ESmad2 ProteinSmad3 ProteinTransforming Growth Factor betaCell transplantationEndothelial progenitor cellsHyperlipidemiaKidney damage

Identifiers

PMID32209093
PMCPMC7093994
OpenAlexW3013512014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.