Evidence map›Paper›PMID 32208998›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2020

Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.

Ying H Shen, Scott A LeMaire, Nancy R Webb, Lisa A Cassis, Alan Daugherty, Hong S Lu

Open access · bronzeAbstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. SPP1BMC medicine · 2026
    Article
  3. Review
  4. Article
  5. Thoracic aortic aneurysm.Nature reviews. Disease primers · 2025
    Review
  6. Anesthetic Considerations for Endovascular Repair of the Thoracic Aorta.Seminars in cardiothoracic and vascular anesthesia · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying H ShenFrom the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX (Y.H.S., S.A.L.).
Scott A LeMaireFrom the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX (Y.H.S., S.A.L.).
Nancy R WebbDepartment of Pharmacology and Nutritional Sciences (N.R.W., L.A.C.), University of Kentucky, Lexington.
Lisa A CassisDepartment of Pharmacology and Nutritional Sciences (N.R.W., L.A.C.), University of Kentucky, Lexington.
Alan DaughertyDepartment of Physiology and Saha Cardiovascular Research Center (A.D., H.S.L.), University of Kentucky, Lexington.
Hong S LuDepartment of Physiology and Saha Cardiovascular Research Center (A.D., H.S.L.), University of Kentucky, Lexington.
Baylor College of Medicine · US

Funding

Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Sex Differences in Angiotensin-Induced Vascular DiseasesR01HL107326 · NHLBI · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2019
$3.7M
Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
Serum Amyloid A, Inflammasome Activation, and Abdominal Aortic AneurysmsR01HL134731 · NHLBI · UNIVERSITY OF KENTUCKY · PI DE BEER, FREDERICK C., WEBB, NANCY R · 2017 to 2020
$2.1M
Atherosclerosis Mechanisms: Angiotensin II production and actionR01HL139748 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN, LU, HONG SHEN · 2018 to 2021
$2.0M
Targeting ER Stress To Treat Aortic Aneurysms and DissectionsR01HL131980 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2016 to 2019
$1.7M
Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and DissectionsR01HL127111 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A · 2016 to 2019
$1.6M
Mitochondrial Damage-Induced Necroptotic Cell Death in SporadicAscending Thoracic Aortic Aneurysms and DissectionsR01HL143359 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A, SHEN, YING H · 2018 to 2021
$1.6M
Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and DissectionsR56HL127111 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LEMAIRE, SCOTT A · 2015 to 2015
$396k
NHLBI NIH HHS R01 HL107326NHLBI NIH HHS R01 HL127111NHLBI NIH HHS R01 HL131980NHLBI NIH HHS R01 HL133723NHLBI NIH HHS R01 HL134731NHLBI NIH HHS R01 HL139748NHLBI NIH HHS R01 HL143359NHLBI NIH HHS R56 HL127111NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in

Indexed as

Signal TransductionAortic AneurysmAortic DissectionExtracellular MatrixHumansMutationReceptors, AngiotensinTransforming Growth Factor betaReceptors, AngiotensinTransforming Growth Factor betaangiotensin II receptoraortaaortic aneurysmssignal transduction pathwaystransforming growth factor

Identifiers

PMID32208998
PMCPMC7122036
OpenAlexW3013821279

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.