Evidence map›Paper›PMID 32208891›Full record

ArticleJournal of neurophysiology2020

Olfactory receptor 78 participates in carotid body response to a wide range of low O

Ying-Jie Peng, Anna Gridina, Benjamin Wang, Jayasri Nanduri, Aaron P Fox, Nanduri R Prabhakar

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Hemoglobin as an oxygen gasoreceptor.Acta biochimica Polonica · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Hypoxia sensing requires HScience advances · 2023
    Article
  9. Constitutive Expression of Hif2α Confers Acute OAdvances in experimental medicine and biology · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ying-Jie PengInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Anna GridinaInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Benjamin WangInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Jayasri NanduriInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Aaron P FoxInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.
Nanduri R PrabhakarInstitute for Integrative Physiology and Center for Systems Biology of O2 Sensing, University of Chicago, Chicago, Illinois.ORCID 0000-0003-4570-1380
University of Chicago · US

Funding

Mechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7M
NHLBI NIH HHS P01 HL144454
6 · The paper itself

Abstract

The role of olfactory receptor 78 (Olfr78) in carotid body (CB) response to hypoxia was examined. BL6 mice with global deletion of Olfr78 manifested an impaired hypoxic ventilatory response (HVR), a hallmark of the CB chemosensory reflex, CB sensory nerve activity, and reduced intracellular Ca

Indexed as

AnimalsCarotid BodyDisease Models, AnimalHypoxiaMiceMice, Inbred C57BLOlfactory Receptor NeuronsOxygenReceptors, OdorantOlfr78 protein, mouseOxygenReceptors, Odorantcarotid bodycarotid body chemosensory reflexglomus cellsG protein-coupled receptorshypoxic ventilatory responseoxygen sensing

Identifiers

PMID32208891
PMCPMC7444916
OpenAlexW3013227421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.