Evidence map›Paper›PMID 32208700›Full record

ArticleThe Journal of organic chemistry2020

Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups.

Akop Yepremyan, Magy A Mekhail, Brian P Niebuhr, Kristof Pota, Nishanth Sadagopan, Timothy M Schwartz, Kayla N Green

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Predicting pRSC advances · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akop YepremyanDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.
Magy A MekhailDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.
Brian P NiebuhrDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.
Kristof PotaDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.
Nishanth SadagopanDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.
Timothy M SchwartzDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.ORCID http://orcid.org/0000-0002-9070-6810
Kayla N GreenDepartment of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie, Fort Worth, Texas 76129, United States.ORCID http://orcid.org/0000-0001-8816-7646

Funding

Targeting oxidative stress in neurodegeneration using pyridol-derived small moleculesR15GM123463 · NIGMS · TEXAS CHRISTIAN UNIVERSITY · PI AKKARAJU, GIRIDHAR, CHUMLEY, MICHAEL J · 2018 to 2025
$1.2M
NIGMS NIH HHS R15 GM123463
6 · The paper itself

Abstract

The number of substituted pyridine pyridinophanes found in the literature is limited due to challenges associated with 12-membered macrocycle and modified pyridine synthesis. Most notably, the electrophilic character at the 4-position of pyridine in pyridinophanes presents a unique challenge for introducing electrophilic chemical groups. Likewise, of the few reported, most substituted pyridine pyridinophanes in the literature are limited to electron-donating functionalities. Herein, new synthetic strategies for four new macrocycles bearing the electron-withdrawing groups CN, Cl, NO

Identifiers

PMID32208700
PMCPMC7301646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.