Evidence map›Paper›PMID 32208663›Full record

ArticleNano letters2020

Programmable Assembly of Iron Oxide Nanoparticles Using DNA Origami.

Travis A Meyer, Chuan Zhang, Gang Bao, Yonggang Ke

Abstract read
In one paragraph

Article in Nano letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Templating Iron(III) Oxides on DNA Molecules.Nanomaterials (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Recent Progress of Magnetically Actuated DNA Micro/Nanorobots.Cyborg and bionic systems (Washington, D.C.) · 2022
    Review
  12. Article
  13. Article
  14. Rationally Programming Nanomaterials with DNA for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  15. DNA Transformations for Diagnosis and Therapy.Advanced functional materials · 2021
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Travis A MeyerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, United States.
Chuan ZhangSchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-9311-0799
Gang BaoDepartment of Bioengineering, Rice University, Houston, Texas 77005, United States.ORCID 0000-0001-5501-554X
Yonggang KeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1673-2153

Funding

DNA origami based molecular probes for quantitative study on TCR/CD8 binding with pMHCsR21AI135753 · NIAID · EMORY UNIVERSITY · PI KE, YONGGANG, ZHU, CHENG · 2018 to 2019
$428k
NIAID NIH HHS R21 AI135753
6 · The paper itself

Abstract

Magnetic iron oxide nanoparticles (IONPs) have received significant interest for the use in biomedical applications. The assembly of IONPs into larger superstructures has been used to modify the properties and functionality of these particles. For example, the clustering of IONPs can lead to improvements in MRI contrast generation, changes in heat generation during magnetic fluid hyperthermia, and alterations to pharmacokinetics and biodistribution. Nevertheless, the IONP clustering leads to significant heterogeneity in the assembly. Here, we demonstrate a method for using DNA origami to precisely control the number and positions of IONPs. We also showed how this technique can be used to module the functionality of IONP clusters by showing how MRI contrast generation efficiency can be tuned by altering the number and spacing of IONPs. Finally, we show that these property changes can be dynamically regulated, demonstrating the possibility for this technology to be used in biosensing applications.

Indexed as

Contrast MediaDimerizationDNAMagnetic Iron Oxide NanoparticlesMagnetic Resonance ImagingNanostructuresNanotechnologyContrast MediaDNADNA OrigamiIron Oxide NanoparticlesMagnetic Resonance Imaging ContrastSelf-Assembly

Identifiers

PMID32208663
PMCPMC7252324

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.