ArticlePloS one2020
Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Deconvolving Phylogenetic Distance Mixtures.bioRxiv : the preprint server for biology · 2026Article
- Goat Milk-Derived Extracellular Vesicles Alleviate Colitis Potentially Through Improved Gut Microbiota in Mice.Foods (Basel, Switzerland) · 2025Article
- After Surgically Induced Remission, Ileal and Colonic Mucosa-Associated Microbiota Predicts Crohn's Disease Recurrence.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.Cellular and molecular life sciences : CMLS · 2024Article
- Results and lessons learned from the sbv IMPROVER metagenomics diagnostics for inflammatory bowel disease challenge.Scientific reports · 2023Article
- Triclosan exposure induced disturbance of gut microbiota and exaggerated experimental colitis in mice.BMC gastroenterology · 2022Article
- Gut microbiota alternation under the intestinal epithelium-specific knockout of mouse Piga gene.Scientific reports · 2022Article
- Shotgun metagenomic sequencing revealed the prebiotic potential of a grain-based diet in mice.Scientific reports · 2022Article
- Impact of dietary fructooligosaccharides (FOS) on murine gut microbiota and intestinal IgA secretion.3 Biotech · 2022Article
- Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis.Microorganisms · 2021Review
- Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease.International journal of molecular sciences · 2021Review
- Probiotics Supplements Reduce ER Stress and Gut Inflammation Associated with Gliadin Intake in a Mouse Model of Gluten Sensitivity.Nutrients · 2021Article
- Altered Gut Microbiota Associated With Hemorrhage in Chronic Radiation Proctitis.Frontiers in oncology · 2021Article
- Optimized Protocol for Characterization of Mouse Gut Innate Lymphoid Cells.Frontiers in immunology · 2020Article
- Crohn's disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice.Gut microbesArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease results from alterations in the immune system and intestinal microbiota. The role of intestinal epithelial cells (IECs) in maintaining gut homeostasis is well known and its perturbation often causes gastrointestinal disorders including IBD. The epithelial specific adaptor protein (AP)-1B is involved in the establishment of the polarity of IECs. Deficiency of the AP-1B μ subunit (Ap1m2-/-) leads to the development of chronic colitis in mice. However, how this deficiency affects the gut microbes and its potential functions remains elusive. To gain insights into the gut microbiome of Ap1m2-/- mice having the colitis phenotype, we undertook shotgun metagenomic sequencing analysis of knockout mice. We found important links to the microbial features involved in altering various physiological pathways, including carbohydrate metabolism, nutrient transportation, oxidative stress, and bacterial pathogenesis (cell motility). In addition, an increased abundance of sulfur-reducing and lactate-producing bacteria has been observed which may aggravate the colitis condition.
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