Evidence map›Paper›PMID 32208171›Full record

ArticleNeuron2020

The Sensory Coding of Warm Perception.

Ricardo Paricio-Montesinos, Frederick Schwaller, Annapoorani Udhayachandran, Florian Rau, Jan Walcher, Roberta Evangelista, Joris Vriens, Thomas Voets, James F A Poulet, Gary R Lewin

Open access · hybridAbstract read
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 195 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. CaCommunications biology · 2026
    Article
  5. The pyrogenic mediator prostaglandin EThe Journal of physiology · 2026
    Article
  6. Review
  7. Temperature effects on taste preferences are influenced by TRPM8.bioRxiv : the preprint server for biology · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. A Reference Atlas of the Human Dorsal Root Ganglion.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. TRPV3 in skin thermosensation and temperature responses.The journal of physiological sciences : JPS · 2025
    Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ricardo Paricio-MontesinosDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany; Neuroscience Research Center and Cluster of Excellence NeuroCure, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
Frederick SchwallerDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany.
Annapoorani UdhayachandranDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany; Neuroscience Research Center and Cluster of Excellence NeuroCure, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
Florian RauDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany; Neuroscience Research Center and Cluster of Excellence NeuroCure, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany.
Jan WalcherDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany.
Roberta EvangelistaDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany.
Joris VriensLaboratory of Endometrium, Endometriosis and Reproductive Medicine, KU Leuven Department of Development and Regeneration, G-PURE, Leuven, Belgium.
Thomas VoetsLaboratory of Ion Channel Research, VIB-KU Leuven Center for Brain and Disease Research, KU Leuven Department of Cellular and Molecular Medicine, Leuven, Belgium.
James F A PouletDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany; Neuroscience Research Center and Cluster of Excellence NeuroCure, Charité-Universitätsmedizin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: james.poulet@mdc-berlin.de.
Gary R LewinDepartment of Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, 13092 Berlin, Germany. Electronic address: glewin@mdc-berlin.de.
Max Delbrück Center · DEKU Leuven · BEVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3

Indexed as

AnimalsMiceMice, KnockoutMutationNerve Fibers, UnmyelinatedNociceptionPerceptionSensory ThresholdsThermosensingTRPM Cation ChannelsTRPV Cation ChannelsUpper ExtremityTRPM2 protein, mouseTRPM8 protein, mouseTRPM Cation ChannelsTRPV1 protein, mouseTRPV Cation ChannelsC-fibernociceptionperceptionpolymodalsensory codingthermal transductionTrp channelswarm

Identifiers

PMID32208171
PMCPMC7272120
OpenAlexW3012761758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.