ArticleBiophysical journal2020
The Poisson Ratio of the Cellular Actin Cortex Is Frequency Dependent.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 42 citations in OpenAlex.
- Real-Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mathematical modelling of mechanotransduction via RhoA signalling pathways.PLoS computational biology · 2025Article
- Transient flow-induced deformation of cancer cells in microchannels: a general computational model and experiments.Biomechanics and modeling in mechanobiology · 2025Article
- Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt.eLife · 2023Article
- Article
- Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation.Advanced healthcare materials · 2023Article
- An explicit model to extract viscoelastic properties of cells from AFM force-indentation curves.iScience · 2022Article
- Collective Cell Migration on Collagen-I Networks: The Impact of Matrix Viscoelasticity.Frontiers in cell and developmental biology · 2022Review
- Poroelastic osmoregulation of living cell volume.iScience · 2021Article
- EMT changes actin cortex rheology in a cell-cycle-dependent manner.Biophysical journal · 2021Article
- Elasticity spectra as a tool to investigate actin cortex mechanics.Journal of nanobiotechnology · 2020Review
- Binding Dynamics of α-Actinin-4 in Dependence of Actin Cortex Tension.Biophysical journal · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell shape changes are vital for many physiological processes such as cell proliferation, cell migration, and morphogenesis. They emerge from an orchestrated interplay of active cellular force generation and passive cellular force response, both crucially influenced by the actin cytoskeleton. To model cellular force response and deformation, cell mechanical models commonly describe the actin cytoskeleton as a contractile isotropic incompressible material. However, in particular at slow frequencies, there is no compelling reason to assume incompressibility because the water content of the cytoskeleton may change. Here, we challenge the assumption of incompressibility by comparing computer simulations of an isotropic actin cortex with tunable Poisson ratio to measured cellular force response. Comparing simulation results and experimental data, we determine the Poisson ratio of the cortex in a frequency-dependent manner. We find that the Poisson ratio of the cortex decreases in the measured frequency regime analogous to trends reported for the Poisson ratio of glassy materials. Our results therefore indicate that actin cortex compression or dilation is possible in response to acting forces at sufficiently fast timescales. This finding has important implications for the parameterization in active gel theories that describe actin cytoskeletal dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.