Evidence map›Paper›PMID 32207871›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Parahydrogen-Induced Radio Amplification by Stimulated Emission of Radiation.

Baptiste Joalland, Nuwandi M Ariyasingha, Sören Lehmkuhl, Thomas Theis, Stephan Appelt, Eduard Y Chekmenev

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Rapid RASER MRI.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing.Angewandte Chemie (International ed. in English) · 2024
    Article
  8. Article
  9. Article
  10. Journal of the American Chemical Society · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. A Versatile Compact Parahydrogen Membrane Reactor.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021
    Article
  17. Article
  18. Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER.Angewandte Chemie (International ed. in English) · 2021
    Article
  19. Article
  20. Low-Flammable Parahydrogen-Polarized MRI Contrast Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baptiste JoallandDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0003-4116-6122
Nuwandi M AriyasinghaDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0001-6601-9909
Sören LehmkuhlDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695-8204, USA.ORCID http://orcid.org/0000-0002-1321-7677
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695-8204, USA.ORCID http://orcid.org/0000-0001-6779-9978
Stephan AppeltInstitut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, 52056, Aachen, Germany.ORCID http://orcid.org/0000-0001-6036-2167
Eduard Y ChekmenevDepartment of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI, 48202, USA.ORCID http://orcid.org/0000-0002-8745-8801

Funding

Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Molecular imaging with a hyperpolarized Vitamin ShotR21EB025313 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2018 to 2019
$661k
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in CancerR21CA220137 · NCI · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2017 to 2019
$390k
Congressionally Directed Medical Research Programs W81XWH-12-1-0159/BC112431Directorate for Mathematical and Physical Sciences CHE-1904780Edward Mallinckrodt, Jr. FoundationNCI NIH HHS 1R21CA220137NCI NIH HHS R21 CA220137NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R21 EB025313NIBIB NIH HHS R21EB025313North Carolina Biotechnology Center 2019-TRG-6707Peer Reviewed Alzheimer's Research Program W81XWH-15-1-0271
6 · The paper itself

Abstract

Radio amplification by stimulated emission of radiation (RASER) was recently discovered in a low-field NMR spectrometer incorporating a highly specialized radio-frequency resonator, where a high degree of proton-spin polarization was achieved by reversible parahydrogen exchange. RASER activity, which results from the coherent coupling between the nuclear spins and the inductive detector, can overcome the limits of frequency resolution in NMR. Here we show that this phenomenon is not limited to low magnetic fields or the use of resonators with high-quality factors. We use a commercial bench-top 1.4 T NMR spectrometer in conjunction with pairwise parahydrogen addition producing proton-hyperpolarized molecules in the Earth's magnetic field (ALTADENA condition) or in a high magnetic field (PASADENA condition) to induce RASER without any radio-frequency excitation pulses. The results demonstrate that RASER activity can be observed on virtually any NMR spectrometer and measures most of the important NMR parameters with high precision.

Indexed as

hyperpolarizationNMR spectroscopyparahydrogenPHIPRASER

Identifiers

PMID32207871
PMCPMC7437572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.