ArticleCancer medicine2020
Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.
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In one paragraph
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis.International journal of biological sciences · 2021Pooled it
- PSMC5 Orchestrates an Immunosuppressive Niche and Metastasis in Colorectal Cancer via SMURF1-Mediated K11-Linked Ubiquitination of METTL14.International journal of biological sciences · 2026Article
- UFMylation Modulates OFIP Stability and Centrosomal Localization.Journal of clinical laboratory analysis · 2025Article
- Characterization of Additive Gene-environment Interactions For Colorectal Cancer Risk.Epidemiology (Cambridge, Mass.) · 2025Article
- Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses.British journal of cancer · 2023Article
- Colon Cancer: From Epidemiology to Prevention.Metabolites · 2022Review
- Sarcoma-180 tumor affects the quality of oocytes in mice.Oncology letters · 2021Article
- Genotype-Based Gene Expression in Colon Tissue-Prediction Accuracy and Relationship with the Prognosis of Colorectal Cancer Patients.International journal of molecular sciences · 2020Article
- Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk.Cancer medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 20 institutions in 10 countries.
Zhiyu XiaDepartment of Epidemiology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8340-8508
Yu-Ru SuPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Paneen PetersenPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lihong QiDepartment of Public Health Sciences, University of California Davis, Davis, CA, USA.
Andre E KimDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-1217-5249
Jane C FigueiredoDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Yi LinPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hongmei NanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Lori C SakodaPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stéphane BézieauService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Stephanie BienPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0003-2225-6675
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
David V ContiDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David A DrewDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Steven J GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
W James GaudermanDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Graham G GilesCancer Epidemiology Division, Melbourne, Victoria, Australia.
Stephen B GruberDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marc J GunterSection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Juan P LewingerDepartment of Preventive Medicine &, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, VA, USA.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Victor MorenoOncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Polly A NewcombDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Shuji OginoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Mingyang SongDivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Xiaoliang WangPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Emily WhiteDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Edward L GiovannucciChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Li HsuPublic Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Ulrike PetersDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
University of Southern California · USFred Hutch Cancer Center · USUniversity of Washington · USHarvard University · USBrigham and Women's Hospital · USCentre international de recherche sur le cancer · FRGerman Cancer Research Center · DENational Institutes of Health · USThe University of Melbourne · AUUniversity of Virginia · USAmerican Cancer Society · USBroad Institute · USCentre Hospitalier Universitaire de Nantes · FRIndiana University Indianapolis · USInstitut d'Investigació Biomédica de Bellvitge · ESKaiser Permanente · USKarolinska Institutet · SEMayo Clinic in Arizona · USMemorial University of Newfoundland · CAMount Sinai Hospital · CA
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MPLCO Trial Etiologic and Early Marker StudyZIACP010152 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MOORE, STEVEN · 2009 to 2025
$29.9MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MUSC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MCancer Research UK C490/A16561Damon Runyon Cancer Research Foundation R01CA136726Intramural NIH HHS Z01 CP010200NCI NIH HHS HHSN261201500005CNCI NIH HHS K05 CA154337NCI NIH HHS L30 CA209764NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NCI NIH HHS Z01 CP010200NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIDDK NIH HHS K01 DK120742NIEHS NIH HHS T32 ES013678NIH HHS HHSN268201100001CNIH HHS HHSN268201100002CNIH HHS HHSN268201100003CNIH HHS HHSN268201100004CNIH HHS HHSN268201100046CNIH HHS HHSN271201100004CNIH HHS K05 CA154337NIH HHS P01 CA033619NIH HHS P01 CA055075NIH HHS P01 CA087969NIH HHS R01 CA042182NIH HHS R01 CA059045NIH HHS R01 CA063464NIH HHS R01 CA076366NIH HHS R01 CA137178NIH HHS R01 CA143247NIH HHS R01 CA151993NIH HHS R35 CA197735NIH HHS T32 ES013678NIH HHS U01 CA074794NIH HHS U01 CA122839NIH HHS U01 CA137088NIH HHS U01 CA164930NIH HHS U01 CA167552NIH HHS UM1 CA167552NIH HHS UM1 CA186107WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
Abstract
backgroundBody mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology.
methodsTo improve statistical power and interpretation for gene-environment interaction (G × E) testing, we tested genetic variants that regulate expression of a gene together for interaction with BMI (kg/m
resultsAmong 4839 genes tested, genetically predicted expressions of FOXA1 (P = 3.15 × 10
conclusionsAggregating G × E interactions and incorporating functional information, we discovered novel genes that may interact with BMI and diabetes on CRC risk.
Indexed as
AgedATPases Associated with Diverse Cellular ActivitiesBody Mass IndexColorectal NeoplasmsDatabases, GeneticDiabetes Mellitus, Type 2FemaleGene ExpressionGenotypeHepatocyte Nuclear Factor 3-alphaHumansMaleMicrotubule-Associated ProteinsMiddle AgedObesityPhenotypeATPases Associated with Diverse Cellular ActivitiesCD33 protein, humanFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaKIAA0753 protein, humanMicrotubule-Associated ProteinsProteasome Endopeptidase ComplexProtein Tyrosine Phosphatase, Non-Receptor Type 2PSMC5 protein, humanPTPN2 protein, humanSCN1B protein, humanSialic Acid Binding Ig-like Lectin 3Voltage-Gated Sodium Channel beta-1 SubunitBMIcolorectal cancerdiabetesgene-environmental interactiongene expression
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