ReviewEndocrinology and metabolism (Seoul, Korea)2020
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations.
Review in Endocrinology and metabolism (Seoul, Korea), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Extracellular Succinate Modulates Neuroimmune Responses in a Murine Microglial Cell Line.Biomolecules · 2026Article
- Harnessing gut microbiota for brain health: protective role of Hungatella hathewayi for post-mTBI cognitive impairment.NPJ biofilms and microbiomes · 2026Article
- Benchmarking the urinary transplant metabolome of kidney transplant recipients using healthy organ donors.Frontiers in transplantation · 2026Article
- Sensing succinate: SUCNR1 as a context-dependent metabolic and cellular signal integrator.Frontiers in molecular biosciences · 2026Review
- Emerging roles of the metabolite succinate in bone-related diseases.Journal of Zhejiang University. Science. B · 2025Review
- Succinate modulates oral dysbiosis and inflammation through a succinate receptor 1 dependent mechanism in aged mice.International journal of oral science · 2025Article
- Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism.The FEBS journal · 2025Article
- Research progress on intratumoral microorganisms in renal cancer.World journal of urology · 2025Review
- Eosinophils in inflammatory bowel disease pathogenesis: an ROS-centric view.Frontiers in allergy · 2025Article
- Ethanol extract of propolis relieves exercise-induced fatigue via modulating the metabolites and gut microbiota in mice.Frontiers in nutrition · 2025Article
- Retinoic Acid-Mediated Control of Energy Metabolism Is Essential for Lung Branching Morphogenesis.International journal of molecular sciences · 2024Article
- Type 2 diabetes and succinate: unmasking an age-old molecule.Diabetologia · 2024Review
- Review
- Complex II Biology in Aging, Health, and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Succinate metabolism and membrane reorganization drives the endotheliopathy and coagulopathy of traumatic hemorrhage.Science advances · 2023Article
- Pharmacokinetics of Succinate in Rats after Intravenous Administration of Mexidol.Bulletin of experimental biology and medicine · 2023Article
- Divulging a Pleiotropic Role of Succinate ReceptorCancers · 2022Article
- Succinate at the Crossroad of Metabolism and Angiogenesis: Roles of SDH, HIF1α and SUCNR1.Biomedicines · 2022Review
- Gemigliptin Alleviates Succinate-Induced Hepatic Stellate Cell Activation by Ameliorating Mitochondrial Dysfunction.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Targeting the succinate receptor effectively inhibits periodontitis.Cell reports · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted succinate's pro-inflammatory role. Taken with the fact that succinate is an intermediate metabolite in the center of mitochondrial activity, and considering its potential regulation of protein succinylation through succinyl-coenzyme A, a review on the overall multifaceted actions of succinate to discuss whether and how these actions relate to the cellular locations of succinate is much warranted. Mechanistically, it is important to consider the sources of succinate, which include somatic cellular released succinate and those produced by the microbiome, especially the gut microbiota, which is an equivalent, if not greater contributor of succinate levels in the body. Continue learning the critical roles of succinate signaling, known and unknown, in many pathophysiological conditions is important. Furthermore, studies to delineate the regulation of succinate levels and to determine how succinate elicits various types of signaling in a temporal and spatial manner are also required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.