SynthesisPaediatric and perinatal epidemiology2020
Composite neonatal morbidity indicators using hospital discharge data: A systematic review.
Synthesis in Paediatric and perinatal epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Weighted and unweighted comorbidity burden for predicting three-year neurodevelopment in extremely preterm infants: A nationwide cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal Adverse Outcomes in Métis Children in Alberta, Canada: A Retrospective Cohort Study.Paediatric and perinatal epidemiology · 2026Article
- Ultrasound-Indicated Versus Physical Examination-Indicated Cerclage in Twin Pregnancies Between 24 and 27 + 6 Weeks: An Exploratory Observational Analysis of Pregnancy and Neonatal Outcomes.Journal of pregnancy · 2026Observational
- Association of maternal primary language with neurodevelopmental outcomes in high-risk infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Prenatal care utilization for fetuses with spina bifida in California.BMC pregnancy and childbirth · 2025Article
- The validity of hospital diagnostic and procedure codes reflecting morbidity in preterm neonates born <32 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The risks of advancing parental age on neonatal morbidity and mortality are U- or J-shaped for both maternal and paternal ages.BMC pediatrics · 2020Article
- Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study.Frontiers in pediatrics · 2020Article
- Growth phenotypes of very low birth weight infants for prediction of neonatal outcomes from a Brazilian cohort: comparison with INTERGROWTH.Jornal de pediatriaArticle
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Authors and funding
7 authors.
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Abstract
backgroundNeonatal morbidity is associated with lifelong impairments, but the absence of a consensual definition and the need for large data sets limit research.
objectivesTo inform initiatives to define standard outcomes for research, we reviewed composite neonatal morbidity indicators derived from routine hospital discharge data. DATA SOURCES: PubMed (updated on October 12, 2018). The search algorithm was based on three components: "morbidity," "neonatal," and "hospital discharge data." STUDY SELECTION AND DATA EXTRACTION: Studies investigating neonatal morbidity using a composite indicator based on hospital discharge data were included. Indicators defined for specific conditions (eg congenital anomalies, maternal addictions) were excluded. The target population, objectives, component morbidities, diagnosis and procedure codes, validation methods, and prevalence of morbidity were extracted. SYNTHESIS: For each study, we assessed construct validity by describing the methods used to select the indicator components and evaluated whether the authors assessed internal and external validity. We also calculated confidence intervals for the prevalence of the morbidity composite.
resultsSeventeen studies fulfilled inclusion criteria. Indicators targeted all (n = 4), low-/moderate-risk (n = 9), and very preterm (VPT, n = 4) infants. Components were similar for VPT infants, but domains and diagnosis codes within domains varied widely for all and low-/moderate-risk infants. Component selection was described for 8/17 indicators and some form of validation reported for 12/17. Neonatal morbidity prevalence ranged from 4.6% to 9.0% of all infants, 0.4% to 8.0% of low-/moderate-risk infants, and 17.8% to 61.0% of VPT infants.
conclusionsMultiple neonatal morbidity indicators based on hospital discharge data have been used for research, but their heterogeneity limits comparisons between studies. Standard neonatal outcome measures are needed for benchmarking and synthesis of research results.
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