SynthesisTechniques in coloproctology2020
Anastomotic leak and cancer-specific outcomes after curative rectal cancer surgery: a systematic review and meta-analysis.
Synthesis in Techniques in coloproctology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anastomotic leak risk factors following colon cancer resection: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- Early postoperative endoscopic evaluation of rectal anastomoses: a prospective cross-sectional study.Surgical endoscopy · 2022Trial
- Observational
- Transanal drainage tube placement in patients with temporary ileostomy after laparoscopic rectal resection for rectal cancer.Updates in surgery · 2026Article
- A Systematic Review and Meta-Analysis of Prediction Scores for Anastomotic Leak Following Colorectal Surgery.Maedica · 2026Review
- Anastomotic leakage after esophagogastric resection increases recurrence risk and impairs long-term survival - a propensity score-matched analysis.BMC surgery · 2026Article
- Significance of nodal yield after rectal resection in the TNT era: does count matter?BMC cancer · 2026Article
- Article
- Risk Factors for and Oncologic Impact of Anastomotic Leakage After Sphincter-Preserving Proctectomy for Mid/Low Rectal Cancer: A Multi-institutional Cohort Study in Japan.Annals of surgical oncology · 2025Article
- ASO Author Reflections: Risk Factors for and the Oncologic Impact of Anastomotic Leakage in Mid-Low Rectal Cancer: A Long-Term Debate.Annals of surgical oncology · 2025Article
- Does robotic circumferential oversewing reduce anastomotic leakage in stapled anastomosis for rectal cancer surgery?Techniques in coloproctology · 2025Article
- Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study.Frontiers in medical technology · 2025Article
- Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study.Journal of the anus, rectum and colon · 2025Article
- What Is the Role of the Gut Microbiota in Anastomotic Leakage After Colorectal Resection? A Scoping Review of Clinical and Experimental Studies.Journal of clinical medicine · 2024Article
- Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation through gut microbiota modulation as a novel therapeutic approach against anastomotic leak after colorectal cancer surgery.Journal of gastrointestinal oncology · 2024Article
- Nomogram for predicting the probability of rectal anastomotic re-leakage after stoma closure: a retrospective study.BMC cancer · 2024Article
- Poly-ϵ-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: an experimental piglet study.BMC gastroenterology · 2024Article
- Validation of an endoscopic anastomotic grading score as an intraoperative method for assessing stapled rectal anastomoses.Techniques in coloproctology · 2023Article
- Review
- C-reactive protein and its ratio are useful indicators to exclude anastomotic leakage requiring intervention after laparoscopic rectal surgery.Updates in surgery · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to perform a systematic review and meta-analysis of cancer-specific outcomes after curative rectal cancer surgery comparing anastomotic leak (AL) with no leak.
methodsPubMed, Medline and Embase databases were searched to identify studies comparing cancer-specific outcomes after rectal cancer surgery in patients with AL and without. A meta-analysis with a random-effects model was used to calculate pooled odds ratios (OR) and confidence intervals (CI) for each outcome measure.
resultsA total of 18 studies were included for meta-analysis, comprising a total of 18,039 patients after curative rectal resection (1764 AL, 16,275 without AL). The overall rate of AL was 9.8%. After AL and excluding 30-day mortality there was an increased risk of local recurrence (OR 1.50; CI 1.23, 1.82), worse overall survival (OR 0.69; CI 0.60-0.81), decreased disease free survival (OR 0.51; CI 0.36-0.73) and cancer specific survival (OR 0.71; CI 0.54-0.94). Distant recurrence (OR 1.10; CI 0.89-1.37) and overall recurrence (OR 1.33; CI 0.64-2.76) were not significantly different between the two groups.
conclusionsAL may negatively impact cancer-specific outcomes after curative rectal cancer surgery and could be considered an independent negative prognostic factor.
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