Evidence map›Paper›PMID 32206896›Full record

ArticleEuropean journal of nutrition2021

Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study.

Federica Laguzzi, Damiano Baldassarre, Fabrizio Veglia, Rona J Strawbridge, Steve E Humphries, Rainer Rauramaa, Andries J Smit, Philippe Giral, Angela Silveira, Elena Tremoli and 5 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Federica LaguzziUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden. federica.laguzzi@ki.se.
Damiano BaldassarreDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Rona J StrawbridgeInstitute of Mental Health and Wellbeing, Mental Health and Wellbeing, University of Glasgow, Glasgow, UK.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute Cardiovascular Science, University College London, London, UK.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Andries J SmitDepartment of Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Philippe GiralAssistance Publique-Hôpitaux de Paris, Service Endocrinologie-Métabolisme, Groupe Hospitalier Pitié-Salpétrière, Unités de Prévention Cardiovasculaire, Paris, France.
Angela SilveiraCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Ulf de FaireUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.
Paolo FrumentoUnit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, 17177, Stockholm, Sweden.
Karin LeanderUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.
IMPROVE Study group

Funding

British Heart Foundation rg2008/008European Commission qlg1ct200200896HDR-UK MR/S003061/1Medical Research Council MR/S003061/1Vetenskapsrådet (SE) 0593Vetenskapsrådet (SE) 8691
6 · The paper itself

Abstract

BACKGROUND/

aimThe association between alcohol consumption and subclinical atherosclerosis is still unclear. Using data from a European multicentre study, we assess subclinical atherosclerosis and its 30-month progression by carotid intima-media thickness (C-IMT) measurements, and correlate this information with self-reported data on alcohol consumption.

methodsBetween 2002-2004, 1772 men and 1931 women aged 54-79 years with at least three risk factors for cardiovascular disease (CVD) were recruited in Italy, France, Netherlands, Sweden, and Finland. Self-reported alcohol consumption, assessed at baseline, was categorized as follows: none (0 g/d), very-low (0 - 5 g/d), low (> 5 to  ≤ 10 g/d), moderate (> 10 to ≤ 20 g/d for women,  > 10 to ≤ 30 g/d for men) and high (> 20 g/d for women, > 30 g/d for men). C-IMT was measured in millimeters at baseline and after 30 months. Measurements consisted of the mean and maximum values of the common carotids (CC), internal carotid artery (ICA), and bifurcations (Bif) and whole carotid tree. We used quantile regression to describe the associations between C-IMT measures and alcohol consumption categories, adjusting for sex, age, physical activity, education, smoking, diet, and latitude.

resultsAdjusted differences between median C-IMT values in different levels of alcohol consumption (vs. very-low) showed that moderate alcohol consumption was associated with lower C-IMT

conclusionIn this European population at high risk of CVD, findings show an inverse relation between moderate alcohol consumption and carotid subclinical atherosclerosis and its 30-month progression, independently of several potential confounders.

Indexed as

AtherosclerosisCarotid Intima-Media ThicknessAlcohol DrinkingFemaleFinlandFranceHumansItalyMaleNetherlandsRisk FactorsSwedenAlcohol drinkingAtherosclerosisCarotid intima-media thicknessEpidemiologyProgression

Identifiers

PMID32206896
PMCPMC7867553

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.