Evidence map›Paper›PMID 32206887›Full record

ArticleParasitology research2020

The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection.

Paul Zaki, Elisa Lbc Domingues, Farhad M Amjad, Maiara B Narde, Karolina R Gonçalves, Mirelle L Viana, Heberth de Paula, Wanderson G de Lima, Huan Huang, Maria T Bahia and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Paul Zaki *Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Elisa Lbc Domingues *Department of Pharmacy and Nutrition, Federal University of Espírito Santo, Guararema, Alegre, ES, 29500-000, Brazil.
Farhad M AmjadDepartment of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Maiara B NardeDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Guararema, Alegre, ES, 29500-000, Brazil.
Karolina R GonçalvesSchool of Medicine, Federal University of Ouro Preto, Morro do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.
Mirelle L VianaDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Guararema, Alegre, ES, 29500-000, Brazil.
Heberth de PaulaDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Guararema, Alegre, ES, 29500-000, Brazil.
Wanderson G de LimaDepartment of Biological Sciences, Federal University of Ouro Preto, Morro do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.
Huan HuangDepartment of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Maria T BahiaSchool of Medicine, Federal University of Ouro Preto, Morro do Cruzeiro, Ouro Preto, MG, 35400-000, Brazil.
Philipp E ShererThe Touchstone Diabetes Center, UT Southwestern Medical Center, 5323 Harry Blvd, Dallas, TX, 75390, USA.
Fabiane M Dos SantosDepartment of Pharmacy and Nutrition, Federal University of Espírito Santo, Guararema, Alegre, ES, 29500-000, Brazil.
Louis M WeissDepartment of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA. louis.weiss@einsteinmed.org.
Herbert B TanowitzDepartment of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Albert Einstein College of Medicine · USUniversidade Federal do Espírito Santo · BRUniversidade Federal de Ouro Preto · BRThe University of Texas Southwestern Medical Center · US

Funding

Adipose tissue Inflammation is a critical mediator of host response to T. cruziR21AI124000 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI TANOWITZ, HERBERT BERNARD · 2016 to 2017
$459k
Effective immunity against Trypanosoma cruzi infection induced by immunizationR21AI142110 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUANG, HUAN · 2019 to 2020
$459k
Trypanosoma cruzi and AIDS: Role of the AdipocyteR21AI068538 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI TANOWITZ, HERBERT BERNARD · 2006 to 2007
$449k
Fundação Estadual de Amparo à Pesquisa do Estado do Espírito Santo 565/2015National Institute of Allergy and Infectious Diseases AI124000NIAID NIH HHS R21 AI068538NIAID NIH HHS R21 AI124000NIAID NIH HHS R21 AI142110United States of America National Institute of Allergy and Infectious Diseases AI124000
6 · The paper itself

Abstract

The underlying pathogenic mechanisms of cardiomyopathy in Chagas disease are still unsolved. In order to better clarify the role of fat on the evolution of cardiomyopathy, the present study employed three murine models of chronic Trypanosoma cruzi infection: (1) aP2-RIDα/β transgenic mice (RID mice; an adipose tissue model which express a gain-of-function potent anti-inflammatory activity), (2) allograft inflammatory factor-1 knockout mice (Aif1

Indexed as

Diet, High-FatTrypanosoma cruziAnimalsChagas CardiomyopathyChagas DiseaseDisease Models, AnimalFemaleHeartInflammationMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMyocardiumParasite LoadTumor Necrosis Factor-alphaAdipose tissueAif-1Fat pro-inflammatory pathwayHigh-fat dietTrypanosoma cruzi

Identifiers

PMID32206887
PMCPMC7263952
OpenAlexW3012730782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.