Evidence map›Paper›PMID 32206865›Full record

Observational studyHeart and vessels2020

Elevated chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes was observed in the patient of atrial fibrillation.

Keisuke Okamura, Tetsu Okuda, Yosuke Takamiya, Kazuyuki Shirai, Hidenori Urata

Abstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Heart and vessels, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Keisuke OkamuraDepartment of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino-shi, Fukuoka, 818-8502, Japan. okamurakmd@cis.fukuoka-u.ac.jp.
Tetsu OkudaDepartment of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino-shi, Fukuoka, 818-8502, Japan.
Yosuke TakamiyaDepartment of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino-shi, Fukuoka, 818-8502, Japan.
Kazuyuki ShiraiDepartment of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino-shi, Fukuoka, 818-8502, Japan.
Hidenori UrataDepartment of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, 1-1-1, Zokumyoin, Chikushino-shi, Fukuoka, 818-8502, Japan.
Fukuoka University · JP

Funding

Japan Society for the Promotion of Science 21590916Japan Society for the Promotion of Science 26461118
6 · The paper itself

Abstract

Chymase is an angiotensin II-forming serine proteinase and elevation of its tissue activity occurs in various cardiovascular diseases. Several authors have suggested that there is an association between the renin-angiotensin system and atrial fibrillation (AF). Chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes (CML chymase dAIIFA) was investigated in patients with AF and patients in sinus rhythm. Consecutive outpatients were recruited at our hospital. CML chymase dAIIFA was measured using a Nma/Dnp-type fluorescence-quenching substrate of modified angiotensin I in the presence or absence of a specific serine proteinase inhibitor. To search the independent contributing factor of existence of AF, the analysis between groups was carried out using multivariate analysis after univariate analysis. The patients were classified into a sinus rhythm (SR) group (n = 459) or an AF group (n = 48). CML chymase dAIIFA was significantly higher in the AF group (622 pmol/min/mg) compared with the SR group (488 pmol/min/mg) (p < 0.001). Logistic regression analysis revealed that high CML chymase dAIIFA was an independent determinant of the existence of AF (p < 0.001). Elevation of CML chymase dAIIFA was associated with AF. Activation of chymase might be linked to atrial structural and electrical remodeling.

Indexed as

Action PotentialsAgedAged, 80 and overAngiotensin IIAtrial FibrillationAtrial RemodelingBiomarkersCase-Control StudiesChymasesCross-Sectional StudiesFemaleHeart RateHumansLeukocytes, MononuclearMaleMiddle AgedAngiotensin IIBiomarkersChymasesAngiotensin II-forming enzyme activityAtrial fibrillationChymaseCirculating mononuclear leukocyteHumanSerine proteinase

Identifiers

PMID32206865
OpenAlexW3012696382

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.