Evidence map›Paper›PMID 32206849›Full record

ReviewExperimental brain research2020

Plasticity and dystonia: a hypothesis shrouded in variability.

Anna Sadnicka, Masashi Hamada

Abstract readReview
In one paragraph

Review in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. A Critical Investigation of Cerebellar Associative Learning in Isolated Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  8. Dystonia.BMJ (Clinical research ed.) · 2022
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna SadnickaMotor Control and Movement Disorders Group, St George's University of London, London, UK. asadnick@sgul.ac.uk.ORCID http://orcid.org/0000-0001-6132-2773
Masashi HamadaDepartment of Neurology, University of Tokyo, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-2866-8067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying plasticity mechanisms with Professor John Rothwell was a shared highlight of our careers. In this article, we discuss non-invasive brain stimulation techniques which aim to induce and quantify plasticity, the mechanisms and nature of their inherent variability and use such observations to review the idea that excessive and abnormal plasticity is a pathophysiological substrate of dystonia. We have tried to define the tone of our review by a couple of Professor John Rothwell's many inspiring characteristics; his endless curiosity to refine knowledge and disease models by scientific exploration and his wise yet humble readiness to revise scientific doctrines when the evidence is supportive. We conclude that high variability of response to non-invasive brain stimulation plasticity protocols significantly clouds the interpretation of historical findings in dystonia research. There is an opportunity to wipe the slate clean of assumptions and armed with an informative literature in health, re-evaluate whether excessive plasticity has a causal role in the pathophysiology of dystonia.

Indexed as

DystoniaDystonic DisordersHumansNeuronal PlasticityDystoniaNeurophysiologyPathophysiologyPlasticity

Identifiers

PMID32206849
PMCPMC7413892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.