Evidence map›Paper›PMID 32206434›Full record

ArticleBiomedical optics express2020

Design of a high-resolution light field miniscope for volumetric imaging in scattering tissue.

Yanqin Chen, Bo Xiong, Yujia Xue, Xin Jin, Joseph Greene, Lei Tian

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanqin ChenShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Bo XiongDepartment of Automation, Tsinghua University, Beijing, 100084, China.
Yujia XueDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Xin JinShenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.ORCID https://orcid.org/0000-0001-6655-3888
Joseph GreeneDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID https://orcid.org/0000-0002-7825-4030
Lei TianDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID https://orcid.org/0000-0002-1316-4456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrating light field microscopy techniques with existing miniscope architectures has allowed for volumetric imaging of targeted brain regions in freely moving animals. However, the current design of light field miniscopes is limited by non-uniform resolution and long imaging path length. In an effort to overcome these limitations, this paper proposes an optimized Galilean-mode light field miniscope (Gali-MiniLFM), which achieves a more consistent resolution and a significantly shorter imaging path than its conventional counterparts. In addition, this paper provides a novel framework that incorporates the anticipated aberrations of the proposed Gali-MiniLFM into the point spread function (PSF) modeling. This more accurate PSF model can then be used in 3D reconstruction algorithms to further improve the resolution of the platform. Volumetric imaging in the brain necessitates the consideration of the effects of scattering. We conduct Monte Carlo simulations to demonstrate the robustness of the proposed Gali-MiniLFM for volumetric imaging in scattering tissue.

Identifiers

PMID32206434
PMCPMC7075622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.