Evidence map›Paper›PMID 32206429›Full record

ArticleBiomedical optics express2020

FlyNet 2.0: drosophila heart 3D (2D + time) segmentation in optical coherence microscopy images using a convolutional long short-term memory neural network.

Zhao Dong, Jing Men, Zhiwen Yang, Jason Jerwick, Airong Li, Rudolph E Tanzi, Chao Zhou

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Attention LSTM U-Net model forBiomedical optics express · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao DongDepartment of Electrical and Computer Engineering, Lehigh University, 27 Memorial Drive W, Bethlehem, PA 18015, USA.
Jing MenDepartment of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Dr., St. Louis, MO 63130, USA.
Zhiwen YangDepartment of Biomedical Engineering, Washington University in St. Louis, 1 Brookings Dr., St. Louis, MO 63130, USA.ORCID https://orcid.org/0000-0002-5712-9695
Jason JerwickDepartment of Electrical and Computer Engineering, Lehigh University, 27 Memorial Drive W, Bethlehem, PA 18015, USA.
Airong LiGenetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
Chao ZhouDepartment of Electrical and Computer Engineering, Lehigh University, 27 Memorial Drive W, Bethlehem, PA 18015, USA.ORCID https://orcid.org/0000-0002-8679-3413

Funding

High throughput optical coherence tomography (OCT)-based imaging platform for label-free, non-invasive characterization of 3D tumor spheroids.R01EB025209 · NIBIB · WASHINGTON UNIVERSITY · PI ZHOU, CHAO · 2017 to 2021
$1.4M
Novel optical imaging and pacing platform for developmental cardiologyR15EB019704 · NIBIB · LEHIGH UNIVERSITY · PI BERDICHEVSKY, YEVGENY · 2015 to 2015
$470k
NIBIB NIH HHS R15 EB019704
6 · The paper itself

Abstract

A custom convolutional neural network (CNN) integrated with convolutional long short-term memory (LSTM) achieves accurate 3D (2D + time) segmentation in cross-sectional videos of the Drosophila heart acquired by an optical coherence microscopy (OCM) system. While our previous FlyNet 1.0 model utilized regular CNNs to extract 2D spatial information from individual video frames, convolutional LSTM, FlyNet 2.0, utilizes both spatial and temporal information to improve segmentation performance further. To train and test FlyNet 2.0, we used 100 datasets including 500,000 fly heart OCM images. OCM videos in three developmental stages and two heartbeat situations were segmented achieving an intersection over union (IOU) accuracy of 92%. This increased segmentation accuracy allows morphological and dynamic cardiac parameters to be better quantified.

Identifiers

PMID32206429
PMCPMC7075608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.