ArticleBiomedical optics express2020
Estimating intracranial pressure using pulsatile cerebral blood flow measured with diffuse correlation spectroscopy.
Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 61 citations in OpenAlex.
- Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation.Journal of biomedical optics · 2026Article
- Toward comprehensive multimodal neuromonitoring of surrogates of cerebral autoregulation in traumatic brain injury: insights from a hyperventilation protocol.Neurophotonics · 2026Article
- Monte Carlo simulations of time-resolved blood flow index: times-of-flight beyond ∼1 ns are necessary for brain-dominated measurements.Neurophotonics · 2026Article
- Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow Response to Intracranial Pressure Elevation.bioRxiv : the preprint server for biology · 2026Article
- Development of a laser speckle contrast imaging analysis pipeline reveals a triphasic retinal blood flow waveform.Biomedical optics express · 2026Article
- Synthetic-data-driven LSTM framework for tracing cardiac pulsation in optical signals.Biomedical optics express · 2025Article
- Comparison of diffuse correlation spectroscopy, interferometric diffusing wave spectroscopy, and speckle contrast optical spectroscopy for blood flow monitoring.Neurophotonics · 2025Article
- Article
- Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Fast Multi-Distance Time-Domain NIRS and DCS System for Clinical Applications.Sensors (Basel, Switzerland) · 2024Article
- ATLAS: a large array, on-chip compute SPAD camera for multispeckle diffuse correlation spectroscopy.Biomedical optics express · 2024Article
- How the heterogeneity of the severely injured brain affects hybrid diffuse optical signals: case examples and guidelines.Neurophotonics · 2024Article
- Stand-alone segmentation of blood flow pulsatility measured with diffuse correlation spectroscopy.Biomedical optics express · 2024Article
- Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension.Biomedical optics express · 2024Article
- Analysis of phase shift between pulse oscillations of macro- and microvascular cerebral blood flow in patients with traumatic brain injury.Acta neurochirurgica · 2024Observational
- Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy.Biomedical optics express · 2024Article
- Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.Biomedical optics express · 2024Article
- Pulsatile microvascular cerebral blood flow waveforms change with intracranial compliance and age.Neurophotonics · 2024Article
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver.Neurophotonics · 2024Article
- The Development of Non-Invasive Optical Brain Pulse Monitoring: A Review.Medical devices (Auckland, N.Z.) · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Measuring intracranial pressure (ICP) is necessary for the treatment of severe head injury but measurement systems are highly invasive and introduce risk of infection and complications. We developed a non-invasive alternative for quantifying ICP using measurements of cerebral blood flow (CBF) by diffuse correlation spectroscopy. The recorded cardiac pulsation waveform in CBF undergoes morphological changes in response to ICP changes. We used the pulse shape to train a randomized regression forest to estimate the underlying ICP and demonstrate in five non-human primates that DCS-based estimation can explain over 90% of the variance in invasively measured ICP.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.