Evidence map›Paper›PMID 32206419›Full record

ArticleBiomedical optics express2020

Co-registered combined OCT and THz imaging to extract depth and refractive index of a tissue-equivalent test object.

A J Fitzgerald, X Tie, M J Hackmann, B Cense, A P Gibson, V P Wallace

Abstract read
In one paragraph

Article in Biomedical optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. TerahertzAPL bioengineering · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A J FitzgeraldDepartment of Physics, The University of Western Australia, Perth, Australia.
X TieDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA.
M J HackmannOptical+Biomedical Engineering Laboratory, Department of Electronic, Electrical and Computer Engineering, The University of Western Australia, Perth, Australia.
B CenseOptical+Biomedical Engineering Laboratory, Department of Electronic, Electrical and Computer Engineering, The University of Western Australia, Perth, Australia.
A P GibsonDepartment of Medical Physics and Biomedical Engineering, University College London, Gower Street, London, WC1E 6BT, UK.ORCID https://orcid.org/0000-0001-9650-5983
V P WallaceDepartment of Physics, The University of Western Australia, Perth, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Terahertz (THz) imaging and optical coherence tomography (OCT) provide complementary information with similar length scales. In addition to OCT's extensive use in ophthalmology, both methods have shown some promise for other medical applications and non-destructive testing. In this paper, we present an iterative algorithm that combines the information from OCT and THz imaging at two different measurement locations within an object to determine both the depth of the reflecting layers at the two locations and the unknown refractive index of the medium for both the OCT wavelengths and THz frequencies. We validate this algorithm using a silicone test object with embedded layers and show that the depths and refractive index values obtained from the algorithm agreed with the measured values to within 3.3%. We further demonstrate for the first time that OCT and THz images can be co-registered and aligned using unsupervised image registration. Hence we show that a combined OCT/THz system can provide unique information beyond the capability of the separate modalities alone, with possible applications in the medical, industrial and pharmaceutical sectors.

Identifiers

PMID32206419
PMCPMC7075603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.