ArticleInternational journal of retina and vitreous2020
Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept-source optical coherence tomography angiography.
Article in International journal of retina and vitreous, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Local Progression Kinetics of Geographic Atrophy Depends Upon the Border Location.Investigative ophthalmology & visual science · 2021Trial
- Faricimab Improves Choriocapillaris Perfusion in Diabetic Macular Edema.Ophthalmology and therapy · 2026Article
- Quantifying Choriocapillaris Flow Deficits in Diabetic Retinopathy Using Projection-Resolved OCT Angiography.Investigative ophthalmology & visual science · 2025Article
- Predictive Vascular Changes in OCTA in Diabetic Patients.Biomedicines · 2025Article
- Advances in OCT Angiography.Translational vision science & technology · 2025Review
- The role of optical coherence tomography angiography in assessing diabetic choroidopathy: a systematic review.International journal of retina and vitreous · 2025Review
- Choriocapillaris flow deficit is associated with disease duration in type 2 diabetic patients without retinopathy: a cross-sectional study.International journal of retina and vitreous · 2024Article
- Optimizing the OCTA layer fusion option for deep learning classification of diabetic retinopathy.Biomedical optics express · 2023Article
- Combining retinal and choroidal microvascular metrics improves discriminative power for diabetic retinopathy.The British journal of ophthalmology · 2023Article
- Macular vascular features of different types of diabetic macular edema using ocular coherence tomography angiography- a comparative study.International journal of retina and vitreous · 2023Article
- Article
- Advances in application of swept-source optical coherence tomography angiography in diagnosis and treatment of diabetic retinopathy.Frontiers in ophthalmology · 2023Review
- Observational
- Topographic analysis of retinal and choroidal microvasculature according to diabetic retinopathy severity using optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Optimizing 3D retinal vasculature imaging in diabetic retinopathy using registration and averaging of OCT-A.Biomedical optics express · 2021Article
- Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundThe purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA).
methodsDiabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations (GEE) approach for clustered eye data was used to determine effect size and significance of age and disease severity on FD % for each region.
results160 eyes from 90 total diabetic patients met inclusion criteria. Out of 90 patients, 33 had no DR, 17 had mild nonproliferative DR (NPDR), 8 had moderate NPDR, 10 had severe NPDR and 22 had proliferative DR. Age and DR severity had a significant positive association with FD % for each region studied with a greater effect in the two centermost regions. The increase in flow deficit percentage per year of age by region was: inner 0.12 (p < 0.001), middle 0.09 (p < 0.001), outer 0.05 (p < 0.001, full-field 0.06 (p < 0.001). The increase in flow deficit percentage per increase in diabetic retinopathy severity stage by region was: inner 0.65 (p < 0.0087), middle 0.56 (p < 0.0012), outer 0.33 (p < 0.045), full-field 0.36 (p < 0.018).
conclusionsTopographic analysis of the CC FD % in diabetic eyes suggests that CC flow impairment corresponds to DR severity, with all studied regions of the CC significantly affected. There was greater regional impairment due to age and disease severity in the inner and middle regions.
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