Evidence map›Paper›PMID 32206306›Full record

ArticlePulmonary circulation

Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension.

Manuel J Richter, Satenik Harutyunova, Tom Bollmann, Simon Classen, Jan Fuge, Henning Gall, Felix Gerhardt, Hossein A Ghofrani, Hartmut Gunkel, Ekkehard Grünig and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 14 institutions in 2 countries.

Manuel J RichterDepartment of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany.
Satenik HarutyunovaCenter for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, Germany.
Tom BollmannDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany.
Simon ClassenDepartment of Vascular Surgery, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany.
Jan FugeGerman Center for Lung Research (DZL), Giessen, Germany.
Henning GallDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany.
Felix GerhardtDepartment III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany.
Hossein A GhofraniDepartment of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany.
Hartmut Gunkelpro-samed GmbH, Berlin, Germany.
Ekkehard GrünigCenter for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, Germany.
Michael HalankDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany.
Alexander HeineDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany.
Hans KloseDepartment of Pneumology, University of Hamburg, Hamburg, Germany.
Tobias J LangeDepartment of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg, Germany.
Claus NeurohrDepartment for Pneumology and Respiratory Medicine, Robert-Bosch-Hospital, Gerlingen, Germany.
Kai NickolausDepartment of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany.
Christian F OpitzDepartment of Cardiology, DRK Kliniken Berlin, Berlin, Germany.
Stephan RosenkranzDepartment III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, Germany.
Hans-Jürgen SeyfarthDepartment of Pneumology, University of Leipzig, Leipzig, Germany.
Khodr TelloDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany.
Ralf EwertDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany.
Karen M OlssonGerman Center for Lung Research (DZL), Giessen, Germany.
Kerckhoff Klinik · DEUniversität Greifswald · DEGerman Center for Lung Research · DEUniversity Hospital Heidelberg · DEUniversity of Cologne · DEDRK Kliniken Berlin · DEJustus-Liebig-Universität Gießen · DERobert Bosch (Germany) · DESamsung (Germany) · DEUniversität Hamburg · DEUniversities of Giessen and Marburg Lung Center · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital Leipzig · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.

Indexed as

implantable infusion pumpprostanoidpulmonary hypertensiontreatment

Identifiers

PMID32206306
PMCPMC7074510
OpenAlexW3006076603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.