Evidence map›Paper›PMID 32206243›Full record

ArticleMedChemComm2019

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

Riyad Domingo, Renier van der Westhuyzen, Anton R Hamann, Konrad J Mostert, Leanne Barnard, Tanya Paquet, Erick T Tjhin, Kevin J Saliba, Willem A L van Otterlo, Erick Strauss

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TheScience advances · 2026
    Article
  2. Article
  3. The mitochondrion ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riyad DomingoDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Renier van der WesthuyzenDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Anton R HamannDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Konrad J MostertDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Leanne BarnardDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Tanya PaquetDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.
Erick T TjhinResearch School of Biology , The Australian National University , Canberra , ACT , Australia.ORCID 0000-0003-1711-0815
Kevin J SalibaResearch School of Biology , The Australian National University , Canberra , ACT , Australia.ORCID 0000-0003-3345-8440
Willem A L van OtterloDepartment of Chemistry and Polymer Science , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa.ORCID 0000-0002-3300-6463
Erick StraussDepartment of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email: estrauss@sun.ac.za.ORCID 0000-0002-9898-8226

Funding

Inhibitors of CoA biosynthesis as novel antitubercular and antistaphylococcal agentsR01AI136836 · NIAID · STELLENBOSCH UNIVERSITY · PI STRAUSS, ERICK · 2018 to 2022
$675k
NIAID NIH HHS R01 AI136836
6 · The paper itself

Abstract

The biosynthesis of the essential metabolic cofactor coenzyme A (CoA) has been receiving increasing attention as a new target that shows potential to counter the rising resistance to established antimicrobials. In particular, phosphopantothenoylcysteine synthetase (PPCS)-the second CoA biosynthesis enzyme that is found as part of the bifunctional CoaBC protein in bacteria, but is monofunctional in eukaryotes-has been validated as a target through extensive genetic knockdown studies in

Identifiers

PMID32206243
PMCPMC7069524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.