ArticleDementia & neuropsychologia
Depressive disorders in the elderly and dementia: An update.
Article in Dementia & neuropsychologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Utilization of CoRDS registry to monitor quality of life in patients with VCP multisystem proteinopathy.Orphanet journal of rare diseases · 2025Article
- The Potential Role of Microbiota in Age-Related Cognitive Decline: A Narrative Review of the Underlying Molecular Mechanisms.International journal of molecular sciences · 2025Review
- Effects of Yoga-Like Exercises on Mild and Moderate Alzheimer Disease: A Randomized Controlled Trial Protocol.La Tunisie medicale · 2025Article
- The conundrum of the connection between severe psychiatric disorders and dementia.Dementia & neuropsychologia · 2025Review
- The impact of sociodemographic and health aspects on cognitive performance in the older adult population in the republic of Serbia.Frontiers in public health · 2024Article
- Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus.Trends in psychiatry and psychotherapy · 2024Article
- The impact of the new model of day care on the mental health status and cognitive functions of patients with disabilities treated in day medical care homes in Poland, 2017-2023.Frontiers in psychiatry · 2024Article
- Subjective cognitive decline, mild cognitive impairment, and dementia - syndromic approach: recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology.Dementia & neuropsychologia · 2022Article
- Differential Diagnosis Findings Between Alzheimer's Disease and Major Depressive Disorder: A Review.Psychiatry and clinical psychopharmacology · 2022Article
- Recognizing Depression in the Elderly: Practical Guidance and Challenges for Clinical Management.Neuropsychiatric disease and treatment · 2022Review
- Foreign Language Learning as Cognitive Training to Prevent Old Age Disorders? Protocol of a Randomized Controlled Trial of Language Training vs. Musical Training and Social Interaction in Elderly With Subjective Cognitive Decline.Frontiers in aging neuroscience · 2021Article
- Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders.Frontiers in medicine · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly - or at least a subgroup of them - and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established.
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