Evidence map›Paper›PMID 32206099›Full record

ArticleTheranostics2020

Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging.

Bowen Qi, Ayrianne J Crawford, Nicholas E Wojtynek, Geoffrey A Talmon, Michael A Hollingsworth, Quan P Ly, Aaron M Mohs

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Preclinical Fluorescence-Guided Imaging Leveraging Surrounding Sentinel Tumor Microenvironment Identifies High-Risk Premalignant Pancreatic Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bowen QiDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Ayrianne J CrawfordEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Nicholas E WojtynekEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Geoffrey A TalmonDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Michael A HollingsworthEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Quan P LyFred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Aaron M MohsDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
University of Nebraska Medical Center · US

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Tissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1M
Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Pancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9M
Hyaluronic Acid Based Nanoparticles for Targeted Image-Guided Tumor SurgeryR01EB019449 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOHS, AARON M. · 2014 to 2017
$1.3M
Nanotechnology for Minimally Invasive Cancer Detection and ResectionR00CA153916 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOHS, AARON M. · 2012 to 2014
$708k
Upgrade of mass spectrometer facilityS10RR017846 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS, MICHAEL J · 2003 to 2003
$497k
Replacement of GC Mass SpectrometerS10RR027940 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI THOMAS, MICHAEL J · 2010 to 2010
$209k
NCI NIH HHS P30 CA036727NCI NIH HHS P50 CA127297NCI NIH HHS R00 CA153916NCI NIH HHS U01 CA210240NCRR NIH HHS S10 RR017846NCRR NIH HHS S10 RR027940NIBIB NIH HHS R01 EB019449NIGMS NIH HHS P20 GM103480
6 · The paper itself

Abstract

The prognosis of pancreatic cancer remains poor. Intraoperative fluorescence imaging of tumors could improve staging and surgical resection, thereby improving prognosis. However, imaging pancreatic cancer with macromolecular delivery systems, is often hampered by nonspecific organ accumulation.

Indexed as

AdenocarcinomaAnimalsContrast MediaDrug Delivery SystemsFemaleFluorescent DyesHyaluronic AcidIntraoperative CareMice, Inbred C57BLMolecular StructurePancreatic NeoplasmsSerum Albumin, BovineContrast MediaFluorescent DyesHyaluronic AcidSerum Albumin, Bovinebiodistributionfluorescence guided surgeryhyaluronic acidPancreatic ductal adenocarcinomaserum protein binding

Identifiers

PMID32206099
PMCPMC7069077
OpenAlexW3006238295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.