Evidence map›Paper›PMID 32206098›Full record

ArticleTheranostics2020

Novel calreticulin-nanoparticle in combination with focused ultrasound induces immunogenic cell death in melanoma to enhance antitumor immunity.

Sri Nandhini Sethuraman, Mohit Pratap Singh, Girish Patil, Shitao Li, Steven Fiering, P Jack Hoopes, Chandan Guha, Jerry Malayer, Ashish Ranjan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  12. Engineering Versatile Nanomedicines for Ultrasonic Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  13. Article
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  16. Article
  17. Article
  18. Review of Robot-Assisted HIFU Therapy.Sensors (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sri Nandhini SethuramanCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Mohit Pratap SinghCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Girish PatilCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Shitao LiCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Steven FieringGeisel School of Medicine, Dartmouth, Hanover, NH03755.
P Jack HoopesGeisel School of Medicine, Dartmouth, Hanover, NH03755.
Chandan GuhaAlbert Einstein College of Medicine, Bronx, New York 10461.
Jerry MalayerCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Ashish RanjanCenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74074.
Oklahoma State University · USDartmouth College · USAlbert Einstein College of Medicine · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Novel focused ultrasound enhanced calreticulin-nanoparticle for immune primed melanoma immunotherapyR37CA239150 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RANJAN, ASHISH · 2019 to 2025
$2.9M
Use of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell toleranceR01CA226861 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GUHA, CHANDAN, MACIAN, FERNANDO · 2018 to 2022
$1.9M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA226861NCI NIH HHS R37 CA239150
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunogenic Cell DeathAdaptive ImmunityAnimalsB7-H1 AntigenCalreticulinCD47 AntigenCD8-Positive T-LymphocytesCell MembraneCombined Modality TherapyCytokinesHumansLymph NodesMelanoma, ExperimentalMiceNanoparticlesSpleenB7-H1 AntigenCalreticulinCALR protein, humanCD274 protein, humanCD47 AntigenCytokinescalreticulinfocused ultrasoundImmunogenic cell deathmelanomananoparticle

Identifiers

PMID32206098
PMCPMC7069083
OpenAlexW3006110498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.