ArticleJournal of biological engineering2020
The head and neck cancer (HN-5) cell line properties extraction by AFM.
Article in Journal of biological engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Ultrasound-induced mechanical damage of cancer cell cytoskeleton causes disruption of nuclear envelope and activation of cGAS-STING.Scientific reports · 2025Article
- Exploring Mechanical Features of 3D Head and Neck Cancer Models.Journal of functional biomaterials · 2025Review
- Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation.Frontiers in oncology · 2022Article
- Review: Cantilever-Based Sensors for High Speed Atomic Force Microscopy.Sensors (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work incorporates experimental methods based on Atomic Force Microscopy (AFM) in order to extract the physical and mechanical characteristics of the head and neck cancer (HN-5) cell line such as cell topography, modulus of elasticity and viscoelastic properties. The initial parameters to determine the mechanical properties are obtained by extracting information from cantilever's force-displacement curve and vertical and horizontal displacement. Next, the changes in elasticity modulus at different points in the cell are attained using the experimental results, followed by studying the differences of these properties at various spots of the cell. Furthermore, cellular folding factor is calculated as a significant property in diagnosing the extent of cancer progression. Moreover, parameters such as adhesion and intermolecular forces are measured which are involved in the first phase of manipulation and during the application of the cantilever force to the particle. Finally, after calculating the indentation depth and contact radius using contact theories, critical manipulation time and force are obtained. Through modeling the cell, the creep function, the spring constant and the damping coefficient corresponding to the cell, are also extracted.
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Registered trials
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