Evidence map›Paper›PMID 32206001›Full record

ReviewWorld journal of gastroenterology2020

Role of alcohol in pathogenesis of hepatitis B virus infection.

Murali Ganesan, Allison Eikenberry, Larisa Y Poluektova, Kusum K Kharbanda, Natalia A Osna

Open access · bronzeAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Trends in Comorbidities and Fatalities Among First-Time Hepatitis B Hospitalizations in Poland (2012-2023).Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  4. Contemporary global epidemiology of cirrhosis.Hepatology communications · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Hepatitis B viral infection and role of alcohol.World journal of gastroenterology · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Murali GanesanResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
Allison EikenberryResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
Larisa Y PoluektovaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Kusum K KharbandaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
Natalia A OsnaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
VA Nebraska Western Iowa Health Care System · USUniversity of Nebraska Medical Center · US

Funding

Ethanol suppresses HBV peptide-MHC Class I presentation on hepatocytesK01AA026864 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GANESAN, MURALI · 2018 to 2022
$684k
NIAAA NIH HHS K01 AA026864
6 · The paper itself

Abstract

Hepatitis B virus (HBV) and alcohol abuse often contribute to the development of end-stage liver disease. Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically. Importantly, the mechanism by which alcohol promotes the progression of HBV-associated liver disease are not completely understood. Potential mechanisms include a suppressed immune response, oxidative stress, endoplasmic reticulum and Golgi apparatus stresses, and increased HBV replication. Certainly, more research is necessary to gain a better understanding of these mechanisms such that treatment(s) to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed. In this review, we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field.

Indexed as

Alcohol DrinkingAlcoholismDisease ProgressionEndoplasmic ReticulumEnd Stage Liver DiseaseGastrointestinal MicrobiomeGolgi ApparatusHepatitis B, ChronicHepatitis B virusHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansLiverOxidative StressVirus ReplicationHistocompatibility Antigens Class IHistocompatibility Antigens Class IIAlcoholHepatitis B virusImmunityLiver diseaseOxidative stress

Identifiers

PMID32206001
PMCPMC7081008
OpenAlexW3009670067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.