Evidence map›Paper›PMID 32205866›Full record

ArticleMolecular psychiatry2020

Early treatment response in first episode psychosis: a 7-T magnetic resonance spectroscopic study of glutathione and glutamate.

Kara Dempster, Peter Jeon, Michael MacKinley, Peter Williamson, Jean Théberge, Lena Palaniyappan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 8 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 8 syntheses or guidelines pooled it, 98 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kara DempsterDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Peter JeonDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.
Michael MacKinleyRobarts Research Institute, London, ON, Canada.
Peter WilliamsonRobarts Research Institute, London, ON, Canada.
Jean ThébergeDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada.ORCID http://orcid.org/0000-0001-7578-4469
Lena PalaniyappanDepartment of Medical Biophysics, University of Western Ontario, London, ON, Canada. lpalaniy@uwo.ca.ORCID http://orcid.org/0000-0003-1640-7182
Western University · CADalhousie University · CARobarts Clinical Trials · CA

Funding

CIHR 375104/2017
6 · The paper itself

Abstract

Early response to antipsychotic medications is one of the most important determinants of later symptomatic and functional outcomes in psychosis. Glutathione and glutamate have emerged as promising therapeutic targets for patients demonstrating inadequate response to dopamine-blocking antipsychotics. Nevertheless, the role of these neurochemicals in the mechanism of early antipsychotic response remains poorly understood. Using a longitudinal design and ultrahigh field 7-T magnetic resonance spectroscopy (MRS) protocol in 53 subjects, we report the association between dorsal anterior cingulate cortex glutamate and glutathione, with time to treatment response in drug naive (34.6% of the sample) or minimally medicated first episode patients with schizophreniform disorder, schizophrenia, and schizoaffective disorder. Time to response was defined as the number of weeks required to reach a 50% reduction in the PANSS-8 scores. Higher glutathione was associated with shorter time to response (F = 4.86, P = 0.017), while higher glutamate was associated with more severe functional impairment (F = 5.33, P = 0.008). There were no significant differences between patients and controls on measures of glutamate or glutathione. For the first time, we have demonstrated an association between higher glutathione and favorable prognosis in FEP. We propose that interventions that increase brain glutathione levels may improve outcomes of early intervention in psychosis.

Indexed as

Antipsychotic AgentsFemaleGlutamic AcidGlutathioneGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance SpectroscopyMalePrognosisPsychotic DisordersSchizophreniaTime FactorsYoung AdultAntipsychotic AgentsGlutamic AcidGlutathione

Identifiers

PMID32205866
PMCPMC7387300
OpenAlexW3012808443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.