ArticleThe Journal of biological chemistry2020
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.
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Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Neuroglobin: A New Player in the Gut-Brain Axis.International journal of molecular sciences · 2026Review
- Continuous extracorporeal hyperoxygenation therapy reduces carbon monoxide half-life time in a carbon monoxide-poisoned pig model: a feasibility study.Scientific reports · 2026Article
- Immobilized neuroglobin scavenges carbon monoxide from circulating carboxyhemoglobin.bioRxiv : the preprint server for biology · 2026Article
- Cytochrome bFree radical biology & medicine · 2026Article
- Acute carbon monoxide poisoning induces renal inflammation and apoptosis via CCL4 upregulation and activation of the PI3K/Akt pathway in mice.Molecular medicine reports · 2025Article
- Carboxyhemoglobin: a potential participant in neonatal hemolytic jaundice accompanied with myocardial injury.European journal of medical research · 2025Review
- CytochromebioRxiv : the preprint server for biology · 2025Article
- CO Complexation by Ru(II) and Os(II) Porphyrin Complexes Sheds Light on the Relative Importance of Thermodynamic Stability and Kinetic Lability for CO Poisoning Antidotes.Organometallics · 2025Article
- Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Extracorporeal hyperoxygenation therapy (EHT) for CO poisoning: in vitro and in vivo feasibility of a full-scale batch system.Scientific reports · 2025Article
- Detoxification of hydrogen sulfide by synthetic heme model compounds.Scientific reports · 2024Article
- Carbon Monoxide: A Pleiotropic Redox Regulator of Life and Death.Antioxidants (Basel, Switzerland) · 2024Review
- Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles.Journal of medicinal chemistry · 2024Review
- Carbon Monoxide Poisoning: From Microbes to Therapeutics.Annual review of medicine · 2024Review
- Carbon monoxide intoxication with a CO-Hb of 30% while smoking waterpipe: a case report.International journal of emergency medicine · 2023Article
- Artificial porphyrin molecules clean up carbon monoxide and cyanide.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell-free and alkylated hemoproteins improve survival in mouse models of carbon monoxide poisoning.JCI insight · 2022Article
- Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response.Pharmacological reviews · 2022Review
- Reversal of Right Ventricular Hypertrophy and Dysfunction by Prostacyclin in a Rat Model of Severe Pulmonary Arterial Hypertension.International journal of molecular sciences · 2022Article
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
Corrections and comments
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Authors and funding
18 authors at 1 institution in 1 country.
Jason J RoseDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 rosejj@upmc.edu.ORCID 0000-0003-1347-9148
Kaitlin A BocianDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Qinzi XuDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Ling WangDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Anthony W DeMartinoDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.ORCID 0000-0001-5303-5758
Xiukai ChenDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Catherine G CoreyDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Danielle A GuimarãesDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Ivan AzarovDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Xueyin N HuangDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Qin TongDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Lanping GuoDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Mehdi NouraieDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Charles F McTiernanDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Christopher P O'DonnellDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Jesús TejeroDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.ORCID 0000-0003-3245-9978
Sruti ShivaDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Mark T GladwinDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
University of Pittsburgh · US
Funding
Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIVA, SRUTI · 2011 to 2020
$26.1MStorage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5MTranslational Training Program in Pulmonary Biology and MedicineT32HL007563 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Melanie Koenigshoff · 1985 to 2026
$12.3MAntidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9MTranslational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0MRole of erythroid DAMP molecules in the pathogenesis of vascular injury in sepsisR01GM113816 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OFORI-ACQUAH, SOLOMON FIIFI, SHIVA, SRUTI · 2015 to 2019
$3.3MNitrite and Hypoxia Increase Mitochondrial Biogenesis and Insulin SensitivityR01HL111706 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI O'DONNELL, CHRISTOPHER P · 2013 to 2016
$1.5MDiscovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular DysfunctionK08HL136857 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSE, JASON J · 2018 to 2022
$970kCountermeasure Therapeutics for Acute Lung InjuryR21ES027390 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEIKAUF, GEORGE DOUGLAS, TEJERO BRAVO, JESUS · 2016 to 2017
$426kCarbon Monoxide Inhibition of Mitochondrial Function and Efficacy of a Novel Antidotal Therapeutic for Carbon Monoxide PoisoningF32HL132418 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSE, JASON J · 2016 to 2017
$97kNHLBI NIH HHS F32 HL132418NHLBI NIH HHS K08 HL136857NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL098032NHLBI NIH HHS R01 HL111706NHLBI NIH HHS R01 HL125886NHLBI NIH HHS T32 HL007563NHLBI NIH HHS T32 HL110849NIEHS NIH HHS R21 ES027390NIGMS NIH HHS R01 GM113816
Abstract
Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome
Indexed as
AnimalsCarbon MonoxideCarbon Monoxide PoisoningCarboxyhemoglobinHumansMaleMiceMitochondria, HeartMitochondria, LiverNeuroglobinNitric OxideOxygen ConsumptionRatsCarbon MonoxideCarboxyhemoglobinNeuroglobinNGB protein, humanNgb protein, mouseNgb protein, ratNitric Oxideantidotescarbon monoxideCO poisoninghemoglobinhypoxiahypoxia-inducible factor (HIF)medical toxicologymitochondriamitochondrial diseasemitochondrial respiratory chain complexneuroglobinnitric oxide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.