Evidence map›Paper›PMID 32205440›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes.

Kevin K Leung, Gary M Wilson, Lisa L Kirkemo, Nicholas M Riley, Joshua J Coon, James A Wells

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. UnderstandingJournal of the American Society for Mass Spectrometry · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Introduction: Methods for Studying the Plasma Membrane and the Surfaceome.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  9. Article
  10. Proximity Labeling of Cell Surface Proteins via Cell Surface Remodeling.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Engineered molecular sensors for quantifying cell surface crowding.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kevin K LeungDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.ORCID 0000-0002-2087-4974
Gary M WilsonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Lisa L KirkemoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Nicholas M RileyDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-1536-2966
Joshua J CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
James A WellsDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143; jim.wells@ucsf.edu.ORCID 0000-0001-8267-5519
University of California, San Francisco · USUniversity of Wisconsin–Madison · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
RESEARCH TRAINING IN CHEMISTRY AND CHEMICAL BIOLOGYT32GM064337 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIK, CHARLES SCOTT · 2002 to 2021
$7.8M
Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolutionR35GM122451 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAMES A WELLS · 2017 to 2026
$5.3M
Uniting Mass Spectrometry and Glycoscience to Investigate Cancer BiologyK00CA212454 · NCI · STANFORD UNIVERSITY · PI RILEY, NICHOLAS M · 2018 to 2021
$331k
NCI NIH HHS K00 CA212454NIGMS NIH HHS P41 GM108538NIGMS NIH HHS R35 GM122451NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM064337
6 · The paper itself

Abstract

The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of

Indexed as

ProteomicsBiomarkers, TumorBreastBreast NeoplasmsCell Line, TumorEpithelial CellsErb-b2 Receptor Tyrosine KinasesErbB ReceptorsFemaleGlycoproteinsHumansMAP Kinase Kinase KinasesMembrane GlycoproteinsOncogene Protein v-aktOncogenesProteomeBiomarkers, TumorBRAF protein, humanEGFR protein, humanERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsGlycoproteinsKRAS protein, humanMAP Kinase Kinase KinasesMembrane GlycoproteinsOncogene Protein v-aktProteomeProto-Oncogene Proteins B-rafProto-Oncogene Proteins p21(ras)glycoproteomicsMAPK signaling pathwayoncogenessurfaceome

Identifiers

PMID32205440
PMCPMC7148585
OpenAlexW3012925937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.