Evidence map›Paper›PMID 32205409›Full record

ArticleMolecular and cellular biology2020

Tumor Necrosis Factor Alpha Regulates Skeletal Myogenesis by Inhibiting SP1 Interaction with

Michael E O'Brien, James Londino, Marcus McGinnis, Nathaniel Weathington, Jessica Adair, Tomeka Suber, Valerian Kagan, Kong Chen, Chunbin Zou, Bill Chen and 2 more

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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  10. Betaine Treatment Prevents TNF-α-Mediated Muscle Atrophy by Restoring Total Protein Synthesis Rate and Morphology in Cultured Myotubes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023
    Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michael E O'Brien *Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
James Londino *Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Davis Heart Lung Research Institute, Columbus, Ohio, USA.
Marcus McGinnisDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nathaniel WeathingtonDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jessica AdairPulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Davis Heart Lung Research Institute, Columbus, Ohio, USA.
Tomeka SuberDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Valerian KaganDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kong ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Chunbin ZouDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bill ChenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jessica BonDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rama K MallampalliPulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Davis Heart Lung Research Institute, Columbus, Ohio, USA rama.mallampalli2@osumc.edu.
University of Pittsburgh · USThe Ohio State University Wexner Medical Center · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
TNF-alpha Control of a Surfactant Enzyme in Lung InjuryR01HL081784 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2006 to 2024
$5.4M
F box-Induced Acute Lung Injury and ParkinR01HL096376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2025
$5.1M
Sepsis-Associated Immune Suppression and F-box ProteinsR01HL097376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2009 to 2025
$5.1M
Stabilizing mitochondria in sepsisR01HL098174 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2021
$3.6M
A New Genus of Ubiquitin-Based Anti-inflammatories for COPDUH2HL123502 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2015
$3.0M
Epigenetic Modulation in Septic ImmunosuppressionR01HL142997 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZOU, CHUNBIN · 2019 to 2022
$1.8M
Epigenetic Regulation in Acute Lung InjuryR01HL125435 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZOU, CHUNBIN · 2015 to 2018
$1.5M
NCI NIH HHS P30 CA047904NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL081784NHLBI NIH HHS R01 HL096376NHLBI NIH HHS R01 HL097376NHLBI NIH HHS R01 HL098174NHLBI NIH HHS R01 HL125435NHLBI NIH HHS R01 HL142997NHLBI NIH HHS UH2 HL123502
6 · The paper itself

Abstract

FBXL2 is an important ubiquitin E3 ligase component that modulates inflammatory signaling and cell cycle progression, but its molecular regulation is largely unknown. Here, we show that tumor necrosis factor alpha (TNF-α), a critical cytokine linked to the inflammatory response during skeletal muscle regeneration, suppressed

Indexed as

Muscle DevelopmentCells, CulturedF-Box ProteinsHumansMuscle, SkeletalMyoblasts, SkeletalPromoter Regions, GeneticRegulatory Sequences, Nucleic AcidSp1 Transcription FactorTumor Necrosis Factor-alphaF-Box ProteinsFBXL2 protein, humanSP1 protein, humanSp1 Transcription FactorTumor Necrosis Factor-alphacell cycledifferentiationFbxl2myoblastmyogenesisproliferationSP1TNF-αtranscriptional regulationubiquitin

Identifiers

PMID32205409
PMCPMC7261720
OpenAlexW3012784489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.