Evidence map›Paper›PMID 32205408›Full record

ArticleMolecular and cellular biology2020

Yeast Sphingolipid Phospholipase Gene

Nabil Matmati, Bachar H Hassan, Jihui Ren, Ashraf A Shamssedine, Eunmi Jeong, Baasil Shariff, Justin Snider, Steven V Rødkær, Guocai Chen, Bidyut K Mohanty and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Improved production of TaxolMicrobial cell factories · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Nabil Matmati *The Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Bachar H Hassan *The Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Jihui RenThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Ashraf A ShamssedineThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Eunmi JeongThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Baasil ShariffThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Justin SniderThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Steven V RødkærVillum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Guocai ChenSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Bidyut K MohantyDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
W Jim ZhengSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Lina M ObeidThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA.
Martin Røssel-LarsenVillum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Nils J FærgemanVillum Center for Bioanalytical Sciences, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Yusuf A HannunThe Stony Brook University Cancer Center, Stony Brook University, Stony Brook, New York, USA yusuf.hannun@stonybrookmedicine.edu.
Stony Brook University · USUniversity of Southern Denmark · DKMedical University of South Carolina · USThe University of Texas Health Science Center at Houston · US

Funding

Sphingolipids in Cancer Therapy and AngiogenesisP01CA097132 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Daniel Canals · 2003 to 2026
$30.8M
THE ROLE OF LACTOSYLCERAMIDE IN RENAL AGING AND DISEASEP20RR017677 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MAO, CUNGUI · 2002 to 2011
$23.4M
THE ROLE OF THE RNA BINDING PROTEIN LA IN ORAL TUMOR BIOLOGYP20RR017696 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SOMMER, GUNHILD · 2002 to 2011
$20.7M
Neutral Sphingomyelinases and Bioactive CeramidesR35GM118128 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI HANNUN, YUSUF AWNI · 2016 to 2025
$7.9M
Bridging Genomics and Medicine by Ontology FingerprintsR56LM010680 · NLM · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LAWSON, ANDREW B. · 2012 to 2013
$499k
NCI NIH HHS P01 CA097132NCRR NIH HHS P20 RR017677NCRR NIH HHS P20 RR017696NIGMS NIH HHS R35 GM118128NLM NIH HHS R56 LM010680
6 · The paper itself

Abstract

Defects in the spindle assembly checkpoint (SAC) can lead to aneuploidy and cancer. Sphingolipids have important roles in many cellular functions, including cell cycle regulation and apoptosis. However, the specific mechanisms and functions of sphingolipids in cell cycle regulation have not been elucidated. Using analysis of concordance for synthetic lethality for the yeast sphingolipid phospholipase

Indexed as

Gene Expression Regulation, FungalCell CycleCell Cycle ProteinsChromosome SegregationChromosomes, FungalGene DeletionGene Regulatory NetworksGenes, FungalProtein Phosphatase 2Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpindle ApparatusType C PhospholipasesCDC55 protein, S cerevisiaeCell Cycle ProteinsISC1 protein, S cerevisiaeProtein Phosphatase 2Saccharomyces cerevisiae ProteinsType C Phospholipasesbudding yeastCDC55cell cycleceramidehydroxyureaISC1phosphoproteomicsspindle checkpointSWE1

Identifiers

PMID32205408
PMCPMC7261723
OpenAlexW3012820448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.