Evidence map›Paper›PMID 32205405›Full record

ArticleInfection and immunity2020

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids.

Jenessa A Winston, Alissa J Rivera, Jingwei Cai, Rajani Thanissery, Stephanie A Montgomery, Andrew D Patterson, Casey M Theriot

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 108 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Expanding bile acid diversityNatural product reports · 2026
    Review
  5. Article
  6. Review
  7. Infection and immunity · 2025
    Article
  8. Roles of Gut Microbiota and Associated Metabolites inPolish journal of microbiology · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jenessa A WinstonDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.ORCID 0000-0001-5323-7683
Alissa J RiveraDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Jingwei CaiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Rajani ThanisseryDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Stephanie A MontgomeryDepartment of Pathology and Laboratory Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-2073-0070
Casey M TheriotDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA cmtherio@ncsu.edu.
North Carolina State University · USPennsylvania State University · USUniversity of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Comparative Medicine and Translational Research Training ProgramT32OD011130 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Lauren Virginia Schnabel · 2012 to 2026
$7.8M
Targeted bacterial restoration of colonization resistance against C. difficileR35GM119438 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THERIOT, CASEY MICHELLE · 2016 to 2020
$1.6M
NCI NIH HHS P30 CA016086NIGMS NIH HHS R35 GM119438NIH HHS T32 OD011130
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBile Acids and SaltsBiomarkersClostridioides difficileClostridium InfectionsComputational BiologyDose-Response Relationship, DrugFibroblast Growth FactorsFragile X Messenger Ribonucleoprotein 1Gastrointestinal MicrobiomeGene Expression ProfilingHost-Pathogen InteractionsHumansLife Cycle StagesMiceSignal TransductionBile Acids and SaltsBiomarkersfibroblast growth factor 15, mouseFibroblast Growth FactorsFragile X Messenger Ribonucleoprotein 1Ursodeoxycholic Acidbile acidsC. difficileFXRinflammationmicrobiomeUDCAursodiol

Identifiers

PMID32205405
PMCPMC7240095
OpenAlexW3012851537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.