Evidence map›Paper›PMID 32205255›Full record

ArticleNeurobiology of disease2020

A recessive Trim2 mutation causes an axonal neuropathy in mice.

Jian J Li, Nicolas Sarute, Eunjoo Lancaster, Guliz Otkiran-Clare, Bani Medegan Fagla, Susan R Ross, Steven S Scherer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  3. Article
  4. PathogenicHuman mutation · 2026
    Article
  5. Article
  6. Neurofilaments in health and Charcot-Marie-Tooth disease.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
  8. Article
  9. Expression and Role of TRIM2 in Human Diseases.BioMed research international · 2022
    Review
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jian J LiDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: LiJian@pennmedicine.upenn.edu.
Nicolas SaruteDepartment of Microbiology and Immunology, UIC College of Medicine, Chicago, IL, USA. Electronic address: sarute@uic.edu.
Eunjoo LancasterDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: eoh@pennmedicine.upenn.edu.
Guliz Otkiran-ClareDepartment of Microbiology and Immunology, UIC College of Medicine, Chicago, IL, USA. Electronic address: gotkir2@uic.edu.
Bani Medegan FaglaDepartment of Microbiology and Immunology, UIC College of Medicine, Chicago, IL, USA. Electronic address: bmedegan@uic.edu.
Susan R RossDepartment of Microbiology and Immunology, UIC College of Medicine, Chicago, IL, USA. Electronic address: srross@uic.edu.
Steven S SchererDepartment of Neurology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sscherer@pennmedicine.edu.
Illinois College · USUniversity of Pennsylvania · US

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROTHMAN, RICHARD E · 2003 to 2013
$91.5M
TRIM2, a novel host factor that restricts New World Arenavirus infectionR21AI112696 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROSS, SUSAN R · 2014 to 2015
$440k
NIAID NIH HHS R21 AI112696NIAID NIH HHS U54 AI057168
6 · The paper itself

Abstract

We analyzed Trim2

Indexed as

MutationAnimalsAxonsCharcot-Marie-Tooth DiseaseIntermediate FilamentsMiceMotor NeuronsTripartite Motif ProteinsUbiquitin-Protein LigasesTrim2 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesAtaxiaAxonal degenerationAxonal spheroidsCerebellumCharcot-Marie-tooth diseaseCMT

Identifiers

PMID32205255
PMCPMC12340668
OpenAlexW3010979599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.