ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients.
Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 14 citations in OpenAlex.
- Pilot study on the use of a multimorbidity index in patients receiving home parenteral nutrition.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- The Prevalence and Impact of Bacteremia Among Neonates Receiving Parenteral Nutrition: A Multicenter Retrospective Study from Saudi Arabia.Pharmacy (Basel, Switzerland) · 2026Article
- Emergency Department Placed Central Lines for Trauma Patients: A Retrospective Case-Control Study on Central Line-Associated Blood Stream Infection Risk From Central Lines Placed Emergently in the Emergency Department.Journal of the American College of Emergency Physicians open · 2025Article
- Levofloxacin prophylaxis and parenteral nutrition have a detrimental effect on intestinal microbial networks in pediatric patients undergoing HSCT.Communications biology · 2023Article
- Effect of supplemental parenteral nutrition on all-cause mortality in critically Ill adults: A meta-analysis and subgroup analysis.Frontiers in nutrition · 2022Article
- The impact of preoperative total parenteral nutrition on the surgical complications of Crohn's disease: A retrospective cohort study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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4 authors at 1 institution in 1 country.
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Abstract
introductionMalnutrition is associated with an increased risk of complications in hospitalized patients, and parenteral nutrition (PN) is used when oral or enteral feeding is not possible. This study aimed at analyzing associations between PN characteristics and infectious complications in hospitalized patients. MATERIAL AND
methodsThis was a retrospective cohort study conducted in a tertiarycare university hospital. Data from consecutive adult patients submitted to PN (January 2016 to December 2017; ICU and ward) were reviewed by means of an electronic database. Patient's clinical characteristics, PN prescription and catheter insertion procedure data were extracted and analyzed. The main outcome was the development of central line-associated bloodstream infection (CLABSI). The secondary outcomes were other infectious complications and mortality, as well as factors associated with CLABSI.
resultsWe analyzed 165 patients and 247 catheters used for parenteral nutrition infusion. The CLABSI rate was 6.47 per 1000 catheter-days. In the univariable analysis, CLABSI was associated with longer hospitalization time, longer PN time, longer catheter time, catheter insertion performed by a surgeon or a surgical resident, and procedures performed outside the ICU. In an extended time-dependent Cox regression, no variable was associated with a higher risk of CLABSI, and additional PN days did not increase the rate of CLABSI. The overall mortality rate was 24.8%. Only the patients' comorbidity index was associated with death in the multivariable analysis. DISCUSSION: In our study, patients who needed PN had an overall CLABSI rate of 6.47 per 1000 catheter-days. These outcomes were not associated with PN and catheter characteristics studied after adjustment for catheter time. The overall mortality rate was 24.8% and it was not associated with PN in multivariable analyses, only with Charlson comorbidity index.
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