Evidence map›Paper›PMID 32204712›Full record

ArticleJournal of translational medicine2020

Circulating PAMM, a novel antioxidant and anti-inflammatory protein, is elevated in acute SCI.

Leslie R Morse, Nguyen Nguyen, Yan Xu, Prakash Jha, Ricardo A Battaglino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Leslie R MorseDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, 55455, USA.
Nguyen NguyenDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, 55455, USA.
Yan XuDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, 55455, USA.
Prakash JhaDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, 55455, USA.
Ricardo A BattaglinoDepartment of Rehabilitation Medicine, University of Minnesota School of Medicine, 500 Boynton Health Service Bridge, 410 Church St. SE, Minneapolis, MN, 55455, USA. rbattagl@umn.edu.
University of Minnesota · US

Funding

Adiposity and Bone Loss in Spinal Cord InjuryR01AR059270 · NIAMS · SPAULDING REHABILITATION HOSPITAL · PI MORSE, LESLIE R. · 2010 to 2014
$3.0M
NIAMS NIH HHS 1R01AR059270-01NIAMS NIH HHS R01 AR059270
6 · The paper itself

Abstract

backgroundPeroxiredoxin activated in M-CSF stimulated monocytes (PAMM) is a novel protein produced by adipocytes with putative redox regulatory and anti-inflammatory properties. Because acute spinal cord injury (SCI) is associated with oxidative stress and neuroinflammation and because PAMM can be detected in systemic circulation, we hypothesized that acute neuro-trauma might induce changes in circulating PAMM expression. Specifically, we hypothesized that PAMM levels might vary based on the presence or absence of acute, traumatic SCI. We therefore investigated circulating PAMM levels in adults with and without acute traumatic SCI.

methodsWe studied 105 men and women (54 with SCI and 51 without SCI). Participants with SCI were admitted for acute rehabilitation within 1 month after injury. Serum samples were obtained during hospitalization and stored at - 80 °C until batch analysis. Total PAMM was quantified by ELISA assay (MyBiosource, Cat. No: MBS9327247) with a detection limit of 0.25 ng/ml. Separate multivariate models including age, BMI, and injury severity were assessed to determine significant clinical predictors of change in PAMM levels.

resultsWhen adjusting for BMI, age, and gender, mean change in PAMM levels were greatest in participants with motor complete SCI compared to able-bodied (1.65 ng/ml versus 0.94 ng/ml, p = 0.003). This model explained 26% of the variation in change in circulating PAMM levels.

conclusionsOur results suggest that PAMM may be a novel biomarker of neurological injury or of native anti-inflammatory responses to neurological injury. More work is needed to establish the role of PAMM and other adipocyte-derived factors in the acute response to neurotrauma.

Indexed as

AntioxidantsSpinal Cord InjuriesAdultAnti-Inflammatory AgentsBiomarkersHumansOxidative StressAnti-Inflammatory AgentsAntioxidantsBiomarkersBiomarkerInflammationPAMMReactive oxygen speciesRehabilitation medicineSpinal cord injury

Identifiers

PMID32204712
PMCPMC7092454
OpenAlexW3012952909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.