Evidence map›Paper›PMID 32204507›Full record

ArticleJournal of clinical medicine2020

Complications in Patients with Acute Myocardial Infarction Supported with Extracorporeal Membrane Oxygenation.

Saraschandra Vallabhajosyula, Malcolm R Bell, Gurpreet S Sandhu, Allan S Jaffe, David R Holmes, Gregory W Barsness

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Saraschandra VallabhajosyulaDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Malcolm R BellDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Gurpreet S SandhuDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Allan S JaffeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
David R HolmesDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Gregory W BarsnessDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
NCATS NIH HHS UL1 TR000135
6 · The paper itself

Abstract

backgroundThere are limited data on complications in acute myocardial infarction (AMI) admissions receiving extracorporeal membrane oxygenation (ECMO).

methodsAdult (>18 years) admissions with AMI receiving ECMO support were identified from the National Inpatient Sample database between 2000 and 2016. Complications were classified as vascular, lower limb amputation, hematologic, and neurologic. Outcomes of interest included temporal trends, in-hospital mortality, hospitalization costs, and length of stay.

resultsIn this 17-year period, in ~10 million AMI admissions, ECMO support was used in 4608 admissions (<0.01%)-mean age 59.5 ± 11.0 years, 75.7% men, 58.9% white race. Median time to ECMO placement was 1 (interquartile range [IQR] 0-3) day. Complications were noted in 2571 (55.8%) admissions-vascular 6.1%, lower limb amputations 1.1%, hematologic 49.3%, and neurologic 9.9%. There was a steady increase in overall complications during the study period (21.1% in 2000 vs. 70.5% in 2016). The cohort with complications, compared to those without complications, had comparable adjusted in-hospital mortality (60.7% vs. 54.0%; adjusted odds ratio 0.89 [95% confidence interval 0.77-1.02]; p = 0.10) but longer median hospital stay (12 [IQR 5-24] vs. 7 [IQR 3-21] days), higher median hospitalization costs ($458,954 [IQR 260,522-737,871] vs. 302,255 [IQR 173,033-623,660]), fewer discharges to home (14.7% vs. 17.9%), and higher discharges to skilled nursing facilities (44.1% vs. 33.9%) (all p < 0.001).

conclusionsOver half of all AMI admissions receiving ECMO support develop one or more severe complications. Complications were associated with higher resource utilization during and after the index hospitalization.

Indexed as

acute myocardial infarctioncomplicationsextracorporeal membrane oxygenationhemorrhagevascular

Identifiers

PMID32204507
PMCPMC7141494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.