Evidence map›Paper›PMID 32204475›Full record

ArticleCells2020

Phenotyping of Rare

Marjolein Ensinck, Liesbeth De Keersmaecker, Lise Heylen, Anabela S Ramalho, Rik Gijsbers, Ricard Farré, Kris De Boeck, Frauke Christ, Zeger Debyser, Marianne S Carlon

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Functional rescue of F508del-CFTR through revertant mutations introduced by CRISPR base editing.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Personalized CFTR Modulator Therapy forInternational journal of molecular sciences · 2023
    Article
  10. An optimized SpCas9 high-fidelity variant for direct protein delivery.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  11. Functional restoration of a CFTR splicing mutation through RNA delivery of CRISPR adenine base editor.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  12. Article
  13. Molecular targets for cystic fibrosis and therapeutic potential of monoclonal antibodies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022
    Review
  14. Review
  15. Article
  16. Assays of CFTR Function In Vitro, Ex Vivo and In Vivo.International journal of molecular sciences · 2022
    Review
  17. Personalized medicine approaches in cystic fibrosis related pancreatitis.American journal of translational research · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Marjolein EnsinckMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Liesbeth De KeersmaeckerMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Lise HeylenMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.ORCID 0000-0002-3623-9000
Anabela S RamalhoCF Centre, Woman and Child Unit, Department of Development and Regeneration, KU Leuven, 3000 Leuven, Flanders, Belgium.
Rik GijsbersMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Ricard FarréTranslational Research in Gastrointestinal Disorders (TARGID), KU Leuven, 3000 Leuven, Flanders, Belgium.ORCID 0000-0001-7158-171X
Kris De BoeckUniversity Hospital Leuven, 3000 Leuven, Flanders, Belgium.
Frauke ChristMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Zeger DebyserMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.
Marianne S CarlonMolecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium.ORCID 0000-0002-8263-0350
KU Leuven · BEVIB-KU Leuven Center for Microbiology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AminopyridinesBenzodioxolesCell MembraneCystic Fibrosis Transmembrane Conductance RegulatorEndoplasmic ReticulumHEK293 CellsHumansMutant ProteinsMutationPhenotypeProtein TransportSubcellular FractionsAminopyridinesBenzodioxolesCystic Fibrosis Transmembrane Conductance RegulatorlumacaftorMutant ProteinsCFTR functionCFTR maturationCFTR modulatorsCFTR traffickingrare CFTR mutations

Identifiers

PMID32204475
PMCPMC7140603
OpenAlexW3010819999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.