Evidence map›Paper›PMID 32204473›Full record

ReviewInternational journal of molecular sciences2020

Extracellular Vesicles in Feto-Maternal Crosstalk and Pregnancy Disorders.

Danilo Buca, Giuseppina Bologna, Alice D'Amico, Sara Cugini, Francesca Musca, Melania Febbo, Dolores D'Arcangelo, Davide Buca, Pasquale Simeone, Marco Liberati and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  5. Pooled it
  6. Maternal Extracellular Vesicles During Pregnancy and Autism Risk in Children.medRxiv : the preprint server for health sciences · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Crosstalk of extracellular vesicles in maternal-fetal interaction.Frontiers in cell and developmental biology · 2026
    Review
  12. Review
  13. Review
  14. Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Danilo BucaDepartment of Obstetrics and Gynecology, University of Chieti, 66100 Chieti, Italy.
Giuseppina BolognaDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Alice D'AmicoDepartment of Obstetrics and Gynecology, University of Chieti, 66100 Chieti, Italy.
Sara CuginiSchool of Medicine and Health Science, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Francesca MuscaSchool of Medicine and Health Science, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Melania FebboSchool of Medicine and Health Science, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Dolores D'ArcangeloSchool of Medicine and Health Science, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.
Davide BucaDepartment of Molecular Medicine and Development, University of Siena, 53100 Siena, Italy.
Pasquale SimeoneDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-4430-480X
Marco LiberatiDepartment of Obstetrics and Gynecology, University of Chieti, 66100 Chieti, Italy.ORCID 0000-0001-7034-0973
Ester VitacolonnaDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0003-1756-661X
Sebastiano MisciaDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Francesco D'AntonioFetal Medicine Unit, Department of Medical and Surgical Sciences, Department of Obstetrics and Gynecology, University of Foggia, 71121 Foggia, Italy.
Paola LanutiDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
University of Chieti-Pescara · ITUniversity of Siena · ITUniversity of Foggia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) actively participate in inter-cellular crosstalk and have progressively emerged as key players of organized communities of cells within multicellular organisms in health and disease. For these reasons, EVs are attracting the attention of many investigators across different biomedical fields. In this scenario, the possibility to study specific placental-derived EVs in the maternal peripheral blood may open novel perspectives in the development of new early biomarkers for major obstetric pathological conditions. Here we reviewed the involvement of EVs in feto-maternal crosstalk mechanisms, both in physiological and pathological conditions (preeclampsia, fetal growth restriction, preterm labor, gestational diabetes mellitus), also underlining the usefulness of EV characterization in maternal-fetal medicine.

Indexed as

Maternal-Fetal ExchangeBiomarkersDiabetes, GestationalExtracellular VesiclesFemaleFetal Growth RetardationHumansPlacentaPre-EclampsiaPregnancyBiomarkersfetal growth restrictiongestational diabetes mellitusplacental extracellular vesiclespre-eclampsiapreterm-laborsyncytiotrophoblast

Identifiers

PMID32204473
PMCPMC7139847
OpenAlexW3011198586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.