Evidence map›Paper›PMID 32204424›Full record

ArticleInternational journal of molecular sciences2020

Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo.

Patrick Belikan, Lisa Nauth, Lars-Christopher Färber, Frédéric Abel, Eva Langendorf, Philipp Drees, Pol Maria Rommens, Ulrike Ritz, Stefan G Mattyasovszky

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Patrick BelikanDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.ORCID 0000-0003-0994-1889
Lisa NauthDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Lars-Christopher FärberDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Frédéric AbelDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Eva LangendorfDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Philipp DreesDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Pol Maria RommensDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Ulrike RitzDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.ORCID 0000-0001-8936-3227
Stefan G MattyasovszkyDepartment of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany.
Johannes Gutenberg University Mainz · DE

Funding

Internal funding programme MAIFOR, University Medical Center, Mainz, Germany MAFOR
6 · The paper itself

Abstract

Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine.

Indexed as

AnimalsAthletic InjuriesGene ExpressionHemeHomeopathyHumansInjections, IntramuscularMaleMineralsModels, AnimalMuscle, SkeletalMyoD ProteinMyogenic Regulatory Factor 5Plant ExtractsRats, WistarRegenerationActoveginHemeMineralsMyoD ProteinMyogenic Regulatory Factor 5Plant ExtractsTraumeel Scalf blood compoundhomeopathic drugintramuscular injectionsmuscle injurymuscle regeneration

Identifiers

PMID32204424
PMCPMC7139694
OpenAlexW3011037915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.