Evidence map›Paper›PMID 32204388›Full record

ArticleSensors (Basel, Switzerland)2020

Monitoring the Heavy Metal Lead Inside Living Drosophila with a FRET-Based Biosensor.

De-Ming Yang, Robeth Viktoria Manurung, Yu-Syuan Lin, Tai-Yu Chiu, Wei-Qun Lai, Yu-Fen Chang, Tsai-Feng Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Genetically encoded fluorescent sensors for metals in biology.Current opinion in chemical biology · 2023
    Review
  2. Portable sensing devices for smart healthcare and prevention of lead poisoning.Journal of the Chinese Medical Association : JCMA · 2023
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

De-Ming YangMicroscopy Service Laboratory, Basic Research Division, Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.ORCID 0000-0002-6923-4855
Robeth Viktoria ManurungResearch Center for Electronics and Telecommunication, Indonesian Institute of Sciences (LIPI), Bandung 40135, Indonesia.ORCID 0000-0001-8641-2249
Yu-Syuan LinInstitute of Biophotonics, School of Medical Technology & Engineering, National Yang-Ming University, Taipei 11221, Taiwan.
Tai-Yu ChiuInstitute of Biophotonics, School of Medical Technology & Engineering, National Yang-Ming University, Taipei 11221, Taiwan.
Wei-Qun LaiMicroscopy Service Laboratory, Basic Research Division, Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Yu-Fen ChangLumiSTAR Biotechnology, Inc., Taipei City 115, Taiwan.
Tsai-Feng FuDepartment of Applied Chemistry, National Chi-Nan University, Nantou 54561, Taiwan.
National Yang Ming Chiao Tung University · TWIndonesian Institute of Sciences · IDNational Chi Nan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 105-2320-B-075-002Ministry of Science and Technology, Taiwan MOST 108-2745-8-075-001
6 · The paper itself

Abstract

The harmful impact of the heavy metal lead on human health has been known for years. However, materials that contain lead remain in the environment. Measuring the blood lead level (BLL) is the only way to officially evaluate the degree of exposure to lead. The so-called "safe value" of the BLL seems to unreliably represent the secure threshold for children. In general, lead's underlying toxicological mechanism remains unclear and needs to be elucidated. Therefore, we developed a novel genetically encoded fluorescence resonance energy transfer (FRET)-based lead biosensor, Met-lead, and applied it to transgenic Drosophila to perform further investigations. We combined Met-lead with the

Indexed as

Biosensing TechniquesAnimalsDrosophila melanogasterLeadMetals, HeavyLeadMetals, HeavybiosensorDrosophilaFRET imagingheavy metal leadMet-lead

Identifiers

PMID32204388
PMCPMC7146181
OpenAlexW3011214634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.