Evidence map›Paper›PMID 32204358›Full record

ArticleMolecules (Basel, Switzerland)2020

Evaluating the Potential of Ursolic Acid as Bioproduct for Cutaneous and Visceral Leishmaniasis.

Pablo Bilbao-Ramos, Dolores R Serrano, Helga Karina Ruiz Saldaña, Juan J Torrado, Francisco Bolás-Fernández, María Auxiliadora Dea-Ayuela

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Anti-Microorganisms · 2024
    Article
  4. Review
  5. Induction of Autophagy by Ursolic Acid Promotes the Elimination ofFrontiers in cellular and infection microbiology · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. (Foods (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pablo Bilbao-RamosDepartament of Microbiology and Parasitology, School of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Dolores R SerranoDepartament of Pharmaceutics and Food Technology, School of Pharmacy, University Complutense, Avenida Complutense, 28040 Madrid, Spain.ORCID 0000-0002-0475-8420
Helga Karina Ruiz SaldañaDepartament of Pharmaceutics and Food Technology, School of Pharmacy, University Complutense, Avenida Complutense, 28040 Madrid, Spain.
Juan J TorradoDepartament of Pharmaceutics and Food Technology, School of Pharmacy, University Complutense, Avenida Complutense, 28040 Madrid, Spain.ORCID 0000-0002-7823-1904
Francisco Bolás-FernándezDepartament of Microbiology and Parasitology, School of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
María Auxiliadora Dea-AyuelaDepartament of Microbiology and Parasitology, School of Pharmacy, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Universidad Complutense de Madrid · ES

Funding

Spanish Agency for International Cooperation and Development A-024457/09 and AP/038991/11Universidad complutense de madrid UCM-Cooperation Program 14-15University CEU-Cardenal Herrera Project PRCEU-UCH09-19
6 · The paper itself

Abstract

Leishmaniasis affects around 12 million people worldwide and is estimated to cause the ninth-largest disease burden. There are three main forms of the disease, visceral (VL), cutaneous (CL), and mucocutaneous (MCL), leading to more than one million new cases every year and several thousand deaths. Current treatments based on chemically synthesized molecules are far from ideal. In this study, we have tested the in vitro and in vivo efficacy of ursolic acid (UA), a multifunctional triterpenoid with well-known antitumoral, antioxidant, and antimicrobial effects on different

Indexed as

Administration, TopicalAnimalsAntiprotozoal AgentsCell LineDisease Models, AnimalHumansInfusions, ParenteralLeishmania infantumLeishmania mexicanaLeishmaniasis, VisceralLiverMaleMesocricetusMicePhytolaccaceaePlant ExtractsAntiprotozoal AgentsPlant ExtractsTriterpenesUrsolic Acidacute-infectionchronic-infectioncutaneous leishmaniasiscytokinesursolic acidvisceral leishmaniasis

Identifiers

PMID32204358
PMCPMC7144553
OpenAlexW3011411416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.