Evidence map›Paper›PMID 32204047›Full record

ArticleMaterials science & engineering. C, Materials for biological applications2020

Porous zinc scaffolds for bone tissue engineering applications: A novel additive manufacturing and casting approach.

Irsalan Cockerill, Yingchao Su, Subhasis Sinha, Yi-Xian Qin, Yufeng Zheng, Marcus L Young, Donghui Zhu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials science & engineering. C, Materials for biological applications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 127 citations in OpenAlex.

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  20. [Research status and development of biodegradable zinc alloy as orthopedics implant].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Irsalan CockerillDepartment of Biomedical Engineering, University of North Texas, Denton, TX 76207, USA; Department of Materials Science and Engineering, University of North Texas, Denton, TX 76207, USA.
Yingchao SuDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
Subhasis SinhaDepartment of Materials Science and Engineering, University of North Texas, Denton, TX 76207, USA.
Yi-Xian QinDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA.
Yufeng ZhengDepartment of Materials Science and Engineering, Peking University, Beijing, China.
Marcus L YoungDepartment of Materials Science and Engineering, University of North Texas, Denton, TX 76207, USA.
Donghui ZhuDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: Donghui.Zhu@stonybrook.edu.
Stony Brook University · USUniversity of North Texas · USPeking University · CN

Funding

Novel surface-modified bioresorbable zinc-based stent materialsR01HL140562 · NHLBI · UNIVERSITY OF NORTH TEXAS · PI Ke Cheng, Donghui Zhu · 2018 to 2026
$4.3M
NHLBI NIH HHS R01 HL140562
6 · The paper itself

Abstract

As a degradable metal, zinc (Zn) has attracted an immense amount of interest as the next generation of bioresorbable implants thanks to its modest corrosion rate and its vital role in bone remodeling, yet very few studies have thoroughly investigated its functionality as a porous implant for bone tissue engineering purposes. Zn bone scaffolds with two different pore sizes of 900 μm and 2 mm were fabricated using additive manufacturing-produced templates combined with casting. The compressive properties, corrosion rates, biocompatibility, and antibacterial performance of the bioscaffolds were examined and compared to a non-porous control. The resulting textured and porous Zn scaffolds exhibit a fully interconnected pore structure with precise control over topology. As pore size and porosity increased, mechanical strength decreased, and corrosion rate accelerated. Cell adhesion and growth on scaffolds were enhanced after an ex vivo pretreatment method. In vitro cellular tests confirmed good biocompatibility of the scaffolds. As porosity increased, potent antibacterial rates were also observed. Taken together, these results demonstrate that Zn porous bone scaffolds are promising for orthopedic applications.

Indexed as

Anti-Bacterial AgentsTissue EngineeringAnimalsBone and BonesCell LineEscherichia coliMiceOsteoblastsPorosityStaphylococcus aureusTissue ScaffoldsZincAnti-Bacterial AgentsZincAntibacterialBiocompatibilityBiodegradableBioscaffoldMaterial extrusion

Identifiers

PMID32204047
PMCPMC7096330
OpenAlexW3004975417

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.