Evidence map›Paper›PMID 32203787›Full record

ArticleEuropean journal of medicinal chemistry2020

Development of potent inhibitors of the human microsomal epoxide hydrolase.

Bogdan Barnych, Nalin Singh, Sophie Negrel, Yue Zhang, Damien Magis, Capucine Roux, Xiude Hua, Zhewen Ding, Christophe Morisseau, Dean J Tantillo and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 2 countries.

Bogdan BarnychDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Nalin SinghDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Sophie NegrelDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Yue ZhangDepartment of Chemistry, University of California Davis, Davis, CA, 95616, United States.
Damien MagisDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Capucine RouxDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Xiude HuaDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States; College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.
Zhewen DingDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Christophe MorisseauDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States.
Dean J TantilloDepartment of Chemistry, University of California Davis, Davis, CA, 95616, United States.
Justin B SiegelDepartment of Chemistry, University of California Davis, Davis, CA, 95616, United States; Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, CA, 95616, United States; Genome Center, University of California Davis, Davis, CA, 95616, United States.
Bruce D HammockDepartment of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California Davis, Davis, CA, 95616, United States. Electronic address: bdhammock@ucdavis.edu.
University of California, Davis · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversityR01GM076324 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2006 to 2019
$3.4M
Omega-3 derived epoxy fatty acids and sEH in pancreatitis-induced carcinogenesisR01DK107767 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YANG, GUANG-YU · 2016 to 2019
$1.9M
NIDDK NIH HHS R01 DK107767NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R35 ES030443NIGMS NIH HHS R01 GM076324
6 · The paper itself

Abstract

Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing molecules. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of certain disease conditions. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more complex and extensive physiological functions. In order to obtain pharmacological tools to further study the biology and therapeutic potential of this enzyme target, we describe the development of highly potent 2-alkylthio acetamide inhibitors of the human mEH with IC

Indexed as

Drug DevelopmentDose-Response Relationship, DrugEnzyme InhibitorsEpoxide HydrolasesHumansMicrosomes, LiverModels, MolecularMolecular StructureStructure-Activity RelationshipEnzyme InhibitorsEpoxide Hydrolases2-Alkylthio acetamide seriesAmidesBenzyl-thioEnzyme inhibitorsMicrosomal epoxide hydrolaseMolecular docking

Identifiers

PMID32203787
PMCPMC7366823
OpenAlexW3011818987

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.