Evidence map›Paper›PMID 32203527›Full record

ArticlePloS one2020

Cervical cancer prevention in Indonesia: An updated clinical impact, cost-effectiveness and budget impact analysis.

Didik Setiawan, Andrijono, Sri Rezeki Hadinegoro, Hashta Meyta, R Vensya Sitohang, Gertrudis Tandy, Dyah Aryani Perwitasari, Maarten J Postma

Abstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Cost-effectiveness analysis of 9-valent human papillomavirus vaccine combined with screening for cervical cancer in Japan.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Herd immunity or health equity? - extending HPV vaccination.The Lancet regional health. Western Pacific · 2023
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Didik SetiawanFaculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Banyumas, Indonesia.ORCID 0000-0001-9104-548X
AndrijonoDivision of Oncology, Department Obstetric and Gynecologic, Cipto Mangunkumo Hospital, Jakarta, Indonesia.
Sri Rezeki HadinegoroDepartment of Child Health, Faculty of Medicine, University of Indonesia, Indonesia.
Hashta MeytaDirectorate General of Diseases Prevention and Control (P2P) Ministry of Health, Indonesia.
R Vensya SitohangDirectorate General of Diseases Prevention and Control (P2P) Ministry of Health, Indonesia.
Gertrudis TandyDirectorate General of Diseases Prevention and Control (P2P) Ministry of Health, Indonesia.
Dyah Aryani PerwitasariFaculty of Pharmacy, Universitas Ahmad Dahlan, Yogyakarta, Indonesia.
Maarten J PostmaUnit of Pharmacoepidemilogy & Pharmacoeconomics (PE2), Department of Pharmacy, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe clinical and economic impact of cervical cancer consistently become a serious burden for all countries, including Indonesia. The implementation of HPV vaccination policy for a big country such as Indonesia requires a strong commitment from several decision-makers. The aim of this study was to provide a comprehensive description on cost-effectiveness and the budget-impact of HPV vaccination policy in Indonesia.

methodA cohort Markov model was used to evaluate the cost and the clinical impact of HPV vaccination for 10 years old girls in Indonesia. The researchers consider two doses of all three available HPV vaccines adjusted with the HPV infection profilewith 95% vaccination coverage to estimate the national cervical cancer incidence and mortality. The Budget impact analysis explores three different scenarios covering (1) Two districts per year expansion, (2) oneprovince per year expansion and (3) achieving the National Immunization Program in 2024.

resultsUpon fully vaccinating almost 2.3 million 10-year-old girls, 34,723; 43,414; and 51,522 cervical cancer cases were prevented by Quadrivalent, Bivalent and Nonavalent vaccines, consecutively. Furthermore, the highest (591 cases) and lowest (399 cases) mortality were prevented by Nonavalent and Quadrivalent vaccines, respectively. Most of the vaccines were considerably cost-effective and only the Bivalent vaccine with the GAVI/UNICEF price which will be considered a cost-saving strategy.To provide national coverage of HPV vaccination in Indonesia, the government has to provide an annual budget of about US$49 million and US$22 million using the government contract price and GAVI/UNICEF price, respectively.

conclusionHPV vaccination shows a cost-effective strategy and the budget required to provide this policy is considerably affordable for Indonesia.

Indexed as

Cost-Benefit AnalysisAdolescentAdultAgedAged, 80 and overBudgetsChildComputer SimulationCost SavingsFemaleHumansIncidenceIndonesiaMarkov ChainsMass VaccinationMiddle AgedPapillomavirus Vaccines

Identifiers

PMID32203527
PMCPMC7089525

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.