ArticleNature neuroscience2020
Recurrent architecture for adaptive regulation of learning in the insect brain.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 183 citations in OpenAlex.
- The larvalScience advances · 2026Article
- Article
- No evidence for aversive associative olfactory memory through metamorphosis in Drosophila.Biology open · 2026Article
- The larvalbioRxiv : the preprint server for biology · 2026Article
- Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- A pair of dopaminergic neurons DAN-c1 mediateeLife · 2025Article
- Article
- Article
- A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain.bioRxiv : the preprint server for biology · 2025Article
- Neural substrates of cold nociception ineLife · 2025Article
- Article
- Brain rewiring during development: A comparative analysis of larval and adultNetwork neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Article
- Hierarchical communities in the larvalProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Beyond prediction error: 25 years of modeling the associations formed in the insect mushroom body.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Roles of feedback and feed-forward networks of dopamine subsystems: insights fromLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 5 countries.
Funding
Abstract
Dopaminergic neurons (DANs) drive learning across the animal kingdom, but the upstream circuits that regulate their activity and thereby learning remain poorly understood. We provide a synaptic-resolution connectome of the circuitry upstream of all DANs in a learning center, the mushroom body of Drosophila larva. We discover afferent sensory pathways and a large population of neurons that provide feedback from mushroom body output neurons and link distinct memory systems (aversive and appetitive). We combine this with functional studies of DANs and their presynaptic partners and with comprehensive circuit modeling. We find that DANs compare convergent feedback from aversive and appetitive systems, which enables the computation of integrated predictions that may improve future learning. Computational modeling reveals that the discovered feedback motifs increase model flexibility and performance on learning tasks. Our study provides the most detailed view to date of biological circuit motifs that support associative learning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.